Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a synergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature.
Virginiamycin B is soluble in ethanol, methanol, DMF and DMSO.
Virginiamycin B is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Virginiamycin B acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A. |
| Molecular Formula | C45H54N8O10 |
| References | Preparation and properties of an antibiotic complex E129. Ball S. Biochem. J. 1958, 68, 24P. Inhibition of protein synthesis by streptogramins and related antibiotics. Cocito C. et al. J. Antimicrob. Chemotherap. 1997, 39, 7. Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms. Porse B. T. and Garrett R. A. J. Mol. Biol. 1999, 286, 375. |
