Colistin Sodium Methanesulfonate is considered an inactive prodrug of colistin, which means it is inactive until converted into colistin by cellular enzymes. It is prepared by the reaction of colistin with formaldehyde, followed by sodium bisulfate. It is also less potent and less toxic than colistin sulfate and is effective against Gram-negative bacteria. Colistin works by targeting the bacterial cell membrane, leading to reduced permeability and cell death. The product is being explored with renewed interest as a possible anti-tuberculosis agent.
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