Milbemycin A4 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of milbemycin A4. Milbemycin A4 oxime is the major component (~70%) in the commercial product, milbemycin oxime, marketed for endo- and exo-parasite infections.
Milbemycin A4 oxime is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Milbemycin A4 oxime is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Mechanism of Action | Like the other milbemycin/avermectins, milbemycin A4 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates, leading to paralysis by hyperpolarisation of these cells and signal transfer blocking. |
| References | Synthesis of 5-keto-5-oxime derivatives of milbemycins and their activities against microfilariae. Tsukamoto Y. et al. Agric. Biol. Chem. 1991, 55, 2615. Effects of milbemycin on adult Toxocara canis in dogs with experimentally induced infection. Bowman D.D. et al. Am. J. Vet. Res. 1988, 49, 1986. |
