Ambuic acid is an antifungal cyclohexanone metabolite produced by Pestalotiopsis sp. Ambuic acid inhibits the biosynthesis of quorum sensing peptides in Gram-positive bacteria. Ambuic acid may exert anti-inflammatory action by blocking the activation of the ERK/JNK MAPK signaling pathway, without the involvement of the p38 MAPK or NF-κB signaling pathways. Ambuic acid demonstrates potent antiproliferative activity.
| Molecular Formula | C19H26O6 |
| References |
Jjiro N et al (2009) Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in Gram-positive bacteria. Antimicrob. Agents Chemother. 53:580 Li JY et al (2001) Ambuic acid, a highly functionalized cyclohexenone with antifungal activity from Pestalotiopsis spp. and Monochaetia sp. Phytochem. 56:463 Zhang Q et al (2018) Anti-inflammatory action of ambuic acid, a natural product isolated from the solid culture of Pestalotiopsis neglecta, through blocking ERK/JNK mitogen-activated protein kinase signaling pathway. Exp. Ther. Med. 16:153 |
