SKU: A205  / 
    CAS Number: 340774-69-8

    Ambuic Acid

    $379.06 - $1,321.33

    Ambuic acid is an antifungal cyclohexanone metabolite produced by Pestalotiopsis sp. Ambuic acid inhibits the biosynthesis of quorum sensing peptides in Gram-positive bacteria. Ambuic acid may exert anti-​inflammatory action by blocking the activation of the ERK​/JNK MAPK signaling pathway, without the involvement of the p38 MAPK or NF-​κB signaling pathways. Ambuic acid demonstrates potent antiproliferative activity.

    Molecular Formula  C19H26O6
    References

    Jjiro N et al (2009)  Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in Gram-positive bacteria. Antimicrob. Agents Chemother. 53:580

    Li JY et al (2001)  Ambuic acid, a highly functionalized cyclohexenone with antifungal activity from Pestalotiopsis spp. and Monochaetia sp.  Phytochem. 56:463

    Zhang Q et al (2018)  Anti-​inflammatory action of ambuic acid, a natural product isolated from the solid culture of Pestalotiopsis neglecta, through blocking ERK​/JNK mitogen-​activated protein kinase signaling pathway. Exp. Ther. Med. 16:153