Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.
Asterric acid is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.
Asterric acid is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.
| References | Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. Lee H.J. et al. , J. Antibiot. 2002, 55, 552. Asterric acid, a new endothelin binding inhibitor. Ohashi H. et al. , J. Antibiot. 1992, 45, 1684. Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol. Mahmoodian A. et al. , Biochem. J. 1964, 92, 369. |
