Cefmetazole is a broad spectrum second generation cephalosporin antibiotic. TOKU-E offers two forms of cefmetazole: cefmetazole, free acid (C122), and cefmetazole sodium (C052). Cefmetazole is freely soluble in water 92 mg/mL.
| Mechanism of Action | Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. |
| Spectrum | Cefmetazole is broad spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria. Cefmetazole is more potent against many Gram-negative enteric flora and pathogens than other first generation cephalosporins. |
| Impurity Profile | Individual impurity: Not more than 1.0% Total impurities: Not more than 2.0 |
| Microbiology Applications | Cefmetazole is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive and Gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
For a complete list of cefmetazole MIC values, click here. |
| Molecular Formula | C15H17N7O5S3 |
| References | Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012. |
| MIC | Bacteroides caccae| 32 － >128|| Bacteroides distasonis| 2 － >128|| Bacteroides eggerthii (ATCC 27754)| 4|| Bacteroides fragilis| 0.06 - >256|| Bacteroides ovatus (ATCC 8483)| 128|| Bacteroides thetaiotaomicron| 8 － >128|| Bacteroides uniformis| 2 － >128|| Bacteroides ureolyticus (NCTC 10941)| 0.25|| Bacteroides vulgatus| 0.12 － >128|| Bifidobacterium adolescentis (ATCC 15703)| 0.25|| Bifidobacterium bifidum (JCM 1255)| 0.25|| Bifidobacterium breve (ATCC 15700)| 4|| Bifidobacterium longum (ATCC 15707)| 4|| Bifidobacterium pseudolongum (ATCC 25526)| 0.5|| Bilophila wadsworthia (WAL 7959)| 8|| Campylobacter gracilis (JCM 8538)| 8|| Capnocytophaga ochracea (GAI 5586)| 2|| Clostridium bifermentans (NCTC 06800)| 0.25|| Clostridium butyricum| 0.06 － 32|| Clostridium clostridioforme| 0.06 － 32|| Clostridium difficile| 8 － >128|| Clostridium paraputrificum (ATCC 25780)| 0.5|| Clostridium perfringens| ≤0.03 － 0.5|| Clostridium putrificum (ATCC 25784)| 0.25|| Clostridium ramosum| 0.06 － 32|| Clostridium septicum| 0.06 － 32|| Clostridium sordellii (NCTC 06929)| 0.5 - 0.25|| Clostridium sporogenes| 0.06 － 32|| Clostridium spp.| ≤0.03 － 0.5|| Desulfovibrio piger (DSM 749)| 16|| Eggerthella lenta (ATCC 25559)| 16|| Finegoldia magna (ATCC 29328)| 0.125 - 2|| Fusobacterium (penicillin-susceptible)| ≤0.015 － 16|| Fusobacterium mortiferum| ≤0.03 － 32|| Fusobacterium necrophorum| ≤0.03 － 32|| Fusobacterium nucleatum| ≤0.03 － 32|| Fusobacterium spp.| ≤0.03 － 32|| Fusobacterium varium| ≤0.03 － 32|| Gemella morbillorum (ATCC 27824)| 0.25|| Klebsiella pneumonia (ESBL)| 4|| Lactobacillus acidophilus (JCM 1132)| 8|| Lactobacillus brevis (JCM 1059)| 64|| Lactobacillus casei (JCM 1134)| 128|| Lactobacillus fermentum (JCM 1173)| 128|| Lactobacillus plantarum (JCM 1149)| >128|| Lactobacillus reuteri (JCM 1112)| >128|| Lactobacillus salivarius (JCM 1231)| 32|| Micromonas micros| 0.25 － 16|| Micromonas micros (VPI 5464-1)| 0.25|| Pasteurella multocida| <4|| Peptoniphilus asaccharolyticus (Levofloxacin-resistant)| 0.125 － 2|| Peptoniphilus indolicus (GAI 0915)| 0.06|| Peptostreptococcus (penicillin-resistant)| ≤0.015 － 16|| Peptostreptococcus anaerobius| ≤0.03 － 128|| Peptostreptococcus magnus| ≤0.03 － 128|| Peptostreptococcus micros| ≤0.03 － 128|| Peptostreptococcus spp.| ≤0.03 － 128|| Porphyromonas (penicillin-susceptible)| ≤0.015 － 1|| Porphyromonas asaccharolytica (ATCC 25260)| 0.125|| Porphyromonas gingivalis (ATCC 33277)| 0.06|| Prevotella bivia (ATCC 29303)| 8|| Prevotella buccae| 0.12 － >128|| Prevotella corporis (GAI 91000)| 0.5|| Prevotella heparinolytica (ATCC 35895)| 0.5|| Prevotella intermedia| 0.12 － >128|| Prevotella melaninogenica| 0.06 － >128|| Prevotella oralis| 0.12 － >128|| Prevotella spp.| 0.06 － >128|| Propionibacterium acnes| 0.06 － 0.25|| Propionibacterium granulosum (ATCC 25564)| 2|| Staphylococcus aureus (352 + methicillin-resistant)| 0.5 － 256|| Staphylococcus saccharolyticus (ATCC 14953)| 0.5|| Streptococci | ≤0.015 － 8|| Streptococcus constellatus| 2|| Streptococcus intermedius (ATCC 27335)| 2|| Sutterella wadsworthensis (ATCC 51579)| 8|| Veillonella dispar (ATCC 17748)| 0.25|| Veillonella parvula| ≤0.03 － 32|| Veillonella spp.| ≤0.03 － 32|| |
