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Detailed Description
CAS Number: 56420-45-2
Molecular Formula: C27H29NO11.HCl
Molecular Weight: 580.0
Tariff Code: 3822.00.5090
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Specifications
Form: Solid
Appearance: Red solid
Source: Synthetic
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Technical Data
Solubility: Soluble in methanol or DMSO
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References
References:
Goldin A et al (1985) The effectiveness of the anthracycline analog 4’-epidoxorubicin in the treatment of experimental tumors: A review. Invest New Drugs 3:3
Nitiss JL (2009) Targeting DNA topoisomerase II in cancer chemotherapy. Nat. Rev. Cancer 9:338
Pang B et al (2013) Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nature Comm. 2013, DOI:10:1038/ncomms 2921
Epirubicin is the 4'-epi-isomer of the antitumor agent, doxorubicin. Epirubicin acts by inhibiting topoisomerase II resulting in DNA double strand breaks. The anthracyclines also act by evicing histone from open chromatin, deregulating the transcriptome in cancer cells and organs. Epirubicin is active against a wide spectrum of experimental tumours including L1210 and P388 leukemias, sarcomas SA180 (solid and ascitic forms), B16 melanoma, mammary carcinoma, Lewis lung carcinoma and colon carcinoma 38
CAS Number: 56420-45-2
Molecular Formula: C27H29NO11.HCl
Molecular Weight: 580.0
Tariff Code: 3822.00.5090
Form: Solid
Appearance: Red solid
Source: Synthetic
Solubility: Soluble in methanol or DMSO
References:
Goldin A et al (1985) The effectiveness of the anthracycline analog 4’-epidoxorubicin in the treatment of experimental tumors: A review. Invest New Drugs 3:3
Nitiss JL (2009) Targeting DNA topoisomerase II in cancer chemotherapy. Nat. Rev. Cancer 9:338
Pang B et al (2013) Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nature Comm. 2013, DOI:10:1038/ncomms 2921
