SKU: E090  / 
    CAS Number: 56420-45-2

    Epirubicin Hydrochloride

    ₱13,930.86 - ₱48,493.50

    Epirubicin is the 4'-epi-isomer of the antitumor agent, doxorubicin. Epirubicin acts by inhibiting topoisomerase II resulting in DNA double strand breaks. The anthracyclines also act by evicing histone from open chromatin, deregulating the transcriptome in cancer cells and organs. Epirubicin is active against a wide spectrum of experimental tumours including L1210 and P388 leukemias, sarcomas SA180 (solid and ascitic forms), B16 melanoma, mammary carcinoma, Lewis lung carcinoma and colon carcinoma 38

    Molecular Formula  C27H29NO11.HCl
    References

    Goldin A et al (1985)  The effectiveness of the anthracycline analog 4’-epidoxorubicin in the treatment of experimental tumors: A review. Invest New Drugs 3:3

    Nitiss JL (2009)  Targeting DNA topoisomerase II in cancer chemotherapy. Nat. Rev. Cancer 9:338

    Pang B et al (2013)  Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.  Nature Comm. 2013, DOI:10:1038/ncomms 2921