Isocyclosporin A is a rearranged degradation product formed by acid treatment of Cyclosporin A under aqueous and non-aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying Cyclosporin A. The pharmacology of Isocyclosporin A has received little attention.
Isocyclosporin A is soluble in ethanol, methanol, DMF or DMSO.
| Molecular Formula | C62H111N11O12 |
| References | Fois RA and Ashley JJJ (1991) Synthesis of a fluorescent derivative of Cyclosporin A for high-performance liquid chromatography analysis. Pharm. Sci. 80:363 Magni F, et al (1995) Hydrolysis of Cyclosporin A: Identification of 1,11 seco-cyclosporin A and 4,5 seco-isocyclosporin A by FAB-MS/MS. Peptides 16(8):1335-1341 PMID 8745041 Oliyai R. et al. (1994) Kinetics of acid-catalyzed degradation of Cyclosporin A and its analogs in aqueous solution. Int. J. Pept. Protein Res. 43(3):239-247 PMID 8005746 Ruegger A (1976) Cyclosporin A, a peptide metabolite from Trichoderma polysporum, (Link ex Pers.) Rifai, with remarkable immunosuppressive activity. Helv. Chim. Acta 59(14):1075-1092 PMID 950308 |