SKU: N085-5G  / 
    CAS Number: 3374-05-8

    Nalidixic Acid Sodium

    $20,562.75
    Nalidixic Acid Sodium
    • Detailed Description

      CAS Number: 3374-05-8

      Molecular Formula: C12H11N2NaO3

      Molecular Weight: 254.22

      Mechanism of Action: Nalidixic Acid indirectly inhibits protein synthesis by binding DNA and interfering with enzymes involved in DNA replication and transcription. In a study with avian myeloblastosis virus RT activity, the presence of adenine in the template made for more efficient inhibition

      Storage Conditions: 2-8°C

      Tariff Code: 2933.49.2600

    • Applications

      Spectrum: Nalidixic Acid is a broad-spectrum antibiotic with activity against Gram-negative and Gram-positive bacteria. The action is primarily bacteriostatic at low levels, and bactericidal at higher concentrations. It is commonly used against bacteria responsible for urinary tract infections.

      Microbiology Applications: Nalidixic Acid is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:

      E. coli 2 µg/mL - 8 µg/mL
      Proteus mirabilis 2.1 µg/mL - 8 µg/mL

    • Specifications

      Form: Powder

      Source: Synthetic

    • Technical Data

      Solubility: Sparingly soluble in water

    • References

      References:

      Aoyama H (1991) Avian myeloblastosis virus reverse transcriptase inhibition by Nalidixic Acid. Mol. Cell Biochem. 108(2):169-174 PMID 1723488

      Kiianitsa K and Maizels M (2014) used Nalidixic Acid Sodium from TOKU-E in: Ultrasensitive isolation, identification and quantification of DNA–protein adducts by ELISA-based RADAR assay. Nucl. Acids Res. 42(13):e108 PMID 24914050 (editor note: please have the PMID # hyperlink to the following URL: https://pubmed.ncbi.nlm.nih.gov/24914050/ )

      Lesher GY, Froelich EJ and Gruett MD, Bailey JH and Brundage RP (1962) 1,0-Naphtyridine derivatives: A new class of chemotherapeutic agents. J. Med. Pharm. Chem. 5:1063-1065 PMID 14056431

      Levitt M et al. (1973) Studies on the mechanism of action of Nalidixic Acid. Antimicrob. Agents Chemother. 4(4):479-486
      Biochemistry, 25: 359-365 PMID 4208771

      Pedrini, A.M., Geroldi, D., Siccardi, A. and Falaschi, A. (1972) Studies on the mode of action of Nalidixic Acid. European Journal of Biochemistry, 25: 359-365 PMID 4625117

    Nalidixic Acid Sodium is a synthetic naphthyridone antibiotic developed by Sanofi Aventis. It is similar in structure and mechanism to quinolones, with a 1,8-naphthyridine nucleus containing 2 nitrogen atoms (unlike quinoline that contains a single nitrogen atom). It is an inhibitor of bacterial DNA polymerase and avian myeloblastoma virus reverse transcriptase. The compound can be used to study bacterial division and apoptosis research. Nalidixic Acid Sodium is sparingly soluble in water.

    CAS Number: 3374-05-8

    Molecular Formula: C12H11N2NaO3

    Molecular Weight: 254.22

    Mechanism of Action: Nalidixic Acid indirectly inhibits protein synthesis by binding DNA and interfering with enzymes involved in DNA replication and transcription. In a study with avian myeloblastosis virus RT activity, the presence of adenine in the template made for more efficient inhibition

    Storage Conditions: 2-8°C

    Tariff Code: 2933.49.2600

    Spectrum: Nalidixic Acid is a broad-spectrum antibiotic with activity against Gram-negative and Gram-positive bacteria. The action is primarily bacteriostatic at low levels, and bactericidal at higher concentrations. It is commonly used against bacteria responsible for urinary tract infections.

    Microbiology Applications: Nalidixic Acid is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:

    E. coli 2 µg/mL - 8 µg/mL
    Proteus mirabilis 2.1 µg/mL - 8 µg/mL

    Form: Powder

    Source: Synthetic

    Solubility: Sparingly soluble in water

    References:

    Aoyama H (1991) Avian myeloblastosis virus reverse transcriptase inhibition by Nalidixic Acid. Mol. Cell Biochem. 108(2):169-174 PMID 1723488

    Kiianitsa K and Maizels M (2014) used Nalidixic Acid Sodium from TOKU-E in: Ultrasensitive isolation, identification and quantification of DNA–protein adducts by ELISA-based RADAR assay. Nucl. Acids Res. 42(13):e108 PMID 24914050 (editor note: please have the PMID # hyperlink to the following URL: https://pubmed.ncbi.nlm.nih.gov/24914050/ )

    Lesher GY, Froelich EJ and Gruett MD, Bailey JH and Brundage RP (1962) 1,0-Naphtyridine derivatives: A new class of chemotherapeutic agents. J. Med. Pharm. Chem. 5:1063-1065 PMID 14056431

    Levitt M et al. (1973) Studies on the mechanism of action of Nalidixic Acid. Antimicrob. Agents Chemother. 4(4):479-486
    Biochemistry, 25: 359-365 PMID 4208771

    Pedrini, A.M., Geroldi, D., Siccardi, A. and Falaschi, A. (1972) Studies on the mode of action of Nalidixic Acid. European Journal of Biochemistry, 25: 359-365 PMID 4625117