Questiomycin A is a phenoxazine produced by several Streptomyces species and some fungi and bacteria. Questiomycin A is weakly active against bacteria, fungi, plants and tumor cell lines, and inhibits aromatase and sulfatases. More recently, questiomycin A has been shown to inhibit pulmonary metastasis caused by mouse melanoma cells. Questiomycin A and related phenoxazines are important dereplication standards in discovery research to eliminate leads due to high amounts of weakly potent actives.
Questiomycin A is soluble in ethanol, methanol, DMF and DMSO.
Questiomycin A is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Questiomycin stimulates cell growth and turnover in vitro, an activity possibly related to their ability to form stable free radicals. |
| Molecular Formula | C12H8N2O2 |
| References | The new antibiotics, questiomycins A and B. Anzai K. et al. J. Antibiot. 1960, 13, 125. Studies on cell growth stimulating substances of low molecular weight. Imai S. et al. J. Antibiot. 1993, 46, 1232. 2-Aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice. Hongo T. J. Pharmacol. Sci. 2010, 114, 63. |