Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Levofloxacin Hydrochloride is the hydrochloride salt of Levofloxacin. It is a broad-spectrum fluoroquinolone antibiotic and the optical S-(-) isomer of Ofloxacin. The compound is a DNA gyrase inhibitor, and has been shown to inhibit topoisomerase...
2’-C-Methylcytidine (syn: 2CMC) is a viral replication inhibitor, shown to be active against multiple viruses including hepatitis C virus (HCV), inhibiting the HCV NS5B RNA polymerase. It is also used against other viruses including Norwalk,...
Ceftiofur Hydrochloride is the hydrochloride salt of Ceftiofur, a broad-spectrum, third-generation β-lactamase resistant cephalosporin commonly used in veterinary research applications that was first described in 1987. Its metabolite...
Bilastine is a second-generation antihistamine used for allergic rhinoconjunctivitis and urticaria (hives). Bilastine also has anti-inflammatory activity.Mechanism of ActionBilastine, a novel molecule, is a selective histamine H1 receptor antagonist. It...
Nalidixic Acid Sodium, CulturePure® is a synthetic 1,8-naphthyridone antibiotic similar in structure and mechanism to quinolones, the commercial preparation of which was developed by Sanofi Aventis. The product is commonly used as a selective...
Sulfamethizole is a broad-spectrum sulfathiazole antibacterial of the Sulfonamide class, used for the bacteria causing urinary tract infections. Acting as a synthetic analog of para-aminobenzoic acid (PABA), it competitively inhibits this...
Oseltamivir Phosphate is an inhibitor of influenza viral neuraminidase. It is also an antiviral used against influenza A and B. Oseltamivir was discovered at Gilead in 1997 using shikimic acid as a starting point for synthesis. The...
Posaconazole is a synthetic, broad-spectrum, second generation triazole with antifungal activity. It has potent in vitro and in vivo trypanocidal activity. It was discovered by Schering-Plough and it is a structural analog of itraconazole. It has...
Ceftazidime Hydrochloride is a non-toxic hydrochloride salt derivative of Ceftazidime, a broad-spectrum, third-generation, β-lactam cephalosporin that interferes with bacterial cell wall synthesis. Patented in 1979 by Glaxo Group, it came into...
Micafungin Sodium is the sodium salt of the semi-synthetic cyclic lipopeptide Micafungin. Micafungin is an antifungal compound belonging to the antifungal class known as echinocandins. It was reported in 1999 by Fujisawa (Japan). It is...
O-Methylviridicatin is a natural derivative of the alkaloid mycotoxin viridicatin produced by several species of Penicillium. The scaffold of quinolin-2(1H)-one is a useful structural motif found in many natural products. In particular,...
Kazusamycin B is a metabolite and minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin A, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and...