Antimicrobials

Tyrocidine

Tyrocidine is a family of eight cationic cyclic decapeptides produced by Bacillus brevis, a soil microorganism.  Tyrocidine was first reported by Dubos in 1941 and was the first commercially available antibiotic, but it was found to have toxicity...

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Usnic acid

Usnic acid is a major metabolite from a number of lichen and fungal species and is perhaps one of the longest known microbial metabolites, first isolated in 1844. Usnic acid exhibits a broad range of biological activity; indeed it is easier to list the...

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Valnemulin

Valnemulin is a semi-synthetic pleuromutilin prepared by sequential reaction of pleuromutilin tosylate with 2-amino-1,1-dimethylethylthiol, coupling the free amine with a protected valine and then deprotection to provide the final product. Valnemulin is...

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Dichlorophen

Dichlorophen is a tenicide, most often used in the treatment of small mammals. Antifungal, antibacterial and herbicidal activity has also been reported. While dichlorophen has low toxicity to mammals, it is toxic to parasites and aquatic life...

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Toyocamycin

Toyocamycin is a pyrrolopyrimidine nucleoside isolated from Streptomyces toyocaensis in 1956. Toyocamycin, like other members of pyrrolopyrimidine class, is an adenosine nucleotide antimetabolite with a broad spectrum of action against bacteria, fungi,...

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Miltefosine

Miltefosine is primarily used as an antileishmanial drug with demonstrated activity against other parasites, cancer cells, and pathogenic bacteria and fungi.Mechanism of ActionSeveral potential antileishmanial mechanisms of action have been proposed...

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Embelin

Embelin is a benzoquinone derivative from the Japanese Ardisia herb. It is a cell-permeable, small-molecule inhibitor of apoptosis regulator proteins. It is a promising start to a new class of anticancer drugs that target apoptosis regulator proteins. It...

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Magainin I

Magainin I is a 23 residue long antimicrobial peptide originally discovered in the skin of Xenopus laevis. It has shown broad-spectrum antibiotic activity, particularly of E. coli, and antifungal activity.TOKU-E also offers: Magainin II (M074) ...

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Poly(vinylpyrrolidone)-Iodine complex

Poly(vinylpyrrolidone)–Iodine complex or "tamed iodine" is used as a topical antiseptic. PVP-I gradually releases active iodine, killling gram-positive and gram-negative bacteria, fungi, parasites, viuses and yeasts.Molecular Formula(C6H9NO)n •...

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Indole-3-carbinol

Indole-3-carbinol is an indole found in many cruciferous vegetables with a variety of bioactivity including anticancer, antibacterial and antifungal effects. Researchers have found that in some cases indole-3-carbinol has inhibited angiogenesis, induced...

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Sulfamethizole

Sulfamethizole is a broad-spectrum sulfathiazole antibacterial of the Sulfonamide class, used for the bacteria causing urinary tract infections.  Acting as a synthetic analog of  para-aminobenzoic acid (PABA), it competitively inhibits this...

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Lactoferricin B, fragment 4-14 trifluoroacetate salt

Lactoferricin B is a broad-spectrum antimicrobial peptide (AMP) that is generated by the enzymatic digestion of lactoferrin. Lactoferricin B is derived from bovine lactoferrin. Lactoferricin B has activity against gram-positive and gram-negative...

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