Antimicrobials

Blasticidin A

Blasticidin A is a high molecular weight tetramic acid isolated from S. resistomycificus in 1955.  It has broad-spectrum antifungal and antibacterial activity.  Like many tetramic acids, Blasticidin A is isolated as the stable calcium...

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Curvularin

Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally...

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Nybomycin

Nybomycin is an unusual heterocyclic metabolite isolated from several Streptomyces species, first reported in 1961 from Streptomyces niveus. Nybomycin possesses antiviral and antibacterial activity. The spectrum of Nybomycin has not been extensively...

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Lasalocid

Lasalocid is a carboxylic polyether ionophore with potent antibacterial activity isolated from Streptomyces lasaliensis, first reported in 1951. It is a mixture of several related homologs(A, B, C, D and E) and  Lasalocid has been found to have...

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Lasalocid Sodium

Lasalocid Sodium is the salt form of Lasalocid, a carboxylic polyether ionophore. The compound has anticancer properties and antibacterial activity. Lasalocid is isolated from Streptomyces lasaliensis, first reported in 1951. It is also known as a...

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Asukamycin

Asukamycin is an unusual trienoic acid amide metabolite produced by Streptomyces nodosus, reported by Omura and colleagues at the Kitasato Institute, Japan, in 1976. Asukamycin belongs to the manumycin class that comprises two trienoic acid amides...

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Equisetin

The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors...

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Feglymycin

Feglymycin is an amphoteric, 13-member, linear peptide featuring 3,5-dihydroxyphenylalanine and a terminal dicarboxylate amino acid, isolated from a Streptomyces in 1999. Feglymycin is a potent antiviral agent with antibacterial activity, including...

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Melittin

Melittin is the principal toxic component of honey bee venom from Apis mellifera, making up 50% of its dry weight. It is a 26 residue long antimicrobial peptide has an α-helical conformation, and associates strongly with membranes. It has demonstrated...

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Cecropin B

Cecropin B is an antimicrobial peptide originally isolated from insects, but now believed to be naturally produced and found in a large variety of organisms including mammals. It has garnered a lot of interest for its broad-spectrum antiparasitic and...

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Pyridomycin

Pyridomycin is a potent antibiotic active against mycobacteria and some Gram negative bacteria, originally isolated from Streptomyces abidoflavus by Umezawa group at the NIH Japan in 1953, and since isolated from different species and published under...

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Cecropin A

Cecropin A is an antimicrobial peptide originally isolated from insects, but now believed to be naturally produced and found in a large variety of organisms including mammals. It has garnered a lot of interest for its broad-spectrum antiparasitic and...

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