Antimicrobials

Cinnamycin

Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium.Cinnamycin is soluble in ethanol, methanol, DMF and DMSO.Mechanism of ActionCinnamycin is a potent indirect inhibitor of...

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Desertomycin A

Desertomycin A is a 42-membered macrocyclic lactone with broad spectrum activity against Gram positive and Gram negative bacteria, yeasts and fungi. There has been little investigation into the mode of action of desertomycin A.Desertomycin A is soluble...

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Kigamicin C

Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal...

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Emodin

Emodin is a tyrosine kinase inhibitor found in multiple plants with a variety of bioactivity including anti-inflammatory, antiviral, antibacterial and anticancer activity. As an anticancer agent it has drawn attention by showing promising therapeutic...

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Chrysomycin B

Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent...

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10'-desmethoxystreptonigrin

10'-Desmethoxystreptonigrin is a close analogue of streptonigrin produced by selected Streptomyces species. It is a moderately potent inhibitor of farnesylation of RAS P21 protein, 3-fold more active than streptonigrin. 10'-Desmethoxystreptonigrin has...

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Capreomycin

Capreomycin is a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. The complex has two major components, IA and IB, with an exocyclic lysine residue and two minor delysinyl components, IIA and IIB. Capreomycin...

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Mithramycin A

Mithramycin A was the first of the aureolic acid class of antitumor antibiotics, isolated from Streptomyces.Mithramycin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.Mechanism of ActionMithramycin inhibits transcription and...

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Demeclocycline

Demeclocycline, a chlortetracycline analog produced by a mutagenised strain of Streptomyces aureofaciens, was first isolated in 1957. Like all tetracyclines, Demeclocycline shows broad-spectrum antibacterial and antiprotozoan activity and acts by binding...

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Meleagrin

Meleagrin is an alkaloid with antitumor and antibiotic activity, isolated from a number of species of Penicillium. Meleagrin is a common taxonomic marker for fungal contamination of foodstuffs. Note that meleagrin, the fungal metabolite, should not be...

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Kazusamycin B

Kazusamycin B is a metabolite and minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin A, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and...

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Doxycycline Hydrate

Doxycycline Hydrate is a third-generation tetracycline and matrix metalloproteinase inhibitor, synthesized in 1958.  It has broad-spectrum antibacterial and antiprotozoan activity, and interferes with bacterial protein synthesis.  It is soluble...

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