Antibacterials

Roccellic Acid

Roccellic Acid is a secondary metabolite and methyldodecylsuccinic acid isolated from lichen Roccella spp. over 150 years ago, with the structure fully elucidated by Akermark in 1962. Roccellic Acid is active against the oral bacteria, Streptococcus...

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Sparsomycin

Sparsomycin is a nucleotide analogue produced by Streptomyces sparsogenes isolated by researchers at Upjohn (now Pfizer) in 1962. Sparsomycin binds to the 50S ribosomal subunit and inhibits protein synthesis via peptidyl transferase inhibition. ...

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Sartorypyrone B

Sartorypyrone B is a pentacyclic meroterpenoid metabolite isolated from Aspergillus (syn. Neosartorya) species. Whilesartorypyrone B possesses no antibiotic activity against S. aureus, P. aeruginosa. B. subtilis and E. coli, it is nonethelessscapable of...

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Streptimidone

Streptimidone (protomycin) is a glutarimide antibiotic isolated from Streptomyces spp. first reported in 1959. Streptimidone is active against a wide spectrum of fungi and protozoans, including Entamoeba hystolica in vitro and in vivo. Streptimidone also...

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Terrelulamide A

Terrelulamide A is a rare lumazine pseudo-tripeptide metabolite isolated from a marine strain of Aspergillus terreus byresearchers at Seoul National University, Korea reported in 2015. Terrelulamide A is reported as having metabolic effects and improves...

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Terpendole I

Terpendole I is a polar analog of a rare family of indolediterpenes isolated from Albophoma yamanashiensis, first reported by Omura and colleagues at the Kitasato Institute, Japan in 1995. Terpendole I is a weak inhibitor of ACAT (acylCoA:cholesterol...

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Tropodithietic Acid

Tropodithietic Acid is a potent antibiotic isolated from a Roseobacter strain by Brinkhoff and colleagues at the University of Gottingen, Germany in 2004. Tropodithietic Acid is a strong inhibitor of marine bacteria, promoter of algal health and a potent...

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Descarbamylnovobiocin

Descarbamylnovobiocin is a member of the novobiocin aminocoumarin antibiotic family found as a minor co-metabolite ofnovobiocin fermentation and produced as an alkaline degradation product. Like novobiocin, Descarbamylnovobiocin is aninhibitor of the...

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Dihydronovobiocin

Dihydronovobiocin is a semi-synthetic member of the novobiocin aminocoumarin antibiotic family prepared by reduction of the prenyl double bond and published in 1956. Dihydronovobiocin is an inhibitor of the bacterial type II topoisomerase, DNA gyrase...

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Levofloxacin Hydrochloride

Levofloxacin Hydrochloride is the hydrochloride salt of Levofloxacin.  It is a broad-spectrum fluoroquinolone antibiotic and the optical S-(-) isomer of Ofloxacin. The compound is a DNA gyrase inhibitor, and has been shown to inhibit topoisomerase...

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Isepamicin Sulfate

Isepamicin sulfate is an aminoglycoside antibiotic derived from gentamicin B.Mechanism of ActionSimilar to other aminoglycosides, isepamicin sulfate binds to the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty...

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Sitafloxacin Hydrate

Sitafloxacin Hydrate is a broad-spectrum fluoroquinoline antibiotic that is particularly active against Gram-positive bacteria such as a pneumococci. Mechanism of Action Sitafloxacin has been shown to have a dual targeted mechanism of action. Other...

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