Antibacterials

WIN 66306

WIN 66306 is a cyclic peptide discovered during a search for inhibitors of Substance P binding to neurokinin (NK) receptors by Sterling Winthrop Pharmaceuticals in 1994. WIN 66306, isolated from Aspergillus sp., is active at both the NK1 and NK2 receptor...

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WF 3681

WF 3681 was isolated from Chaetomella sp. as a novel inhibitor of aldose reductase by researchers at Fujisawa Co. Japan in 1987, exhibiting an IC50 of 2.5 x 10-7 M. WF 3681 does not significantly reduce accumulation of sorbitol in rat sciatic nerves of...

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WEB 2086

WEB 2086 (apafant) is a potent and selective platelet activating (PAF) antagonist. WEB 2086 has high affinity for guinea pig peritoneal macrophage PAF receptors, dissociating slowly. WEB 2086 at 10-8 to 10-6 mol​/L strongly and...

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Turmerone

Turmerone is a non-polar 1,4-dialkylaryl metabolite isolated as a constituent of essential oil from turmeric (Curcuma longa), a plant with medicinal and culinary use. Turmerone has antimicrobial, insecticidal, larvicidal and antivenom properties against...

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Thaxtomin A

Thaxtomin A is a unique dioxopiperazine containing a 4-nitroindol-3-yl moiety isolated by scientists at Dow Agrisciences from Streptomyces scabies, the causative agent of common scab on new potatoes in 1989. Thaxtomin A is the predominant and most active...

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Syringic Acid

Syringic Acid, the 3,5-dimethyl ether derivative of gallic acid, is a phenolic compound found in fruits and vegetables which is synthesized via the shikimic acid pathway in plants. Syringic Acid has a broad bioprofile, having antioxidant,...

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Streptomycin

Streptomycin, a metabolite of Streptomyces griseus, was first published as an antibiotic active against Gram-positive and Gram-negative bacteria by Schatz, Bugie and Waksman in 1944. Streptomycin was the first aminoglycoside antibiotic and first agent...

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1,3-Diphenylurea

1,3-Diphenylurea is an endogenous metabolite of plants present in coconut milk (Cocos nucifera) amonth other sources. In combination with casein hydrolysate, 1,3-diphenylurea promotes transport of photosynthetic products in the vascular tissue of carrots...

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spiro-Oxanthromicin A

spiro-Oxanthromicin was first isolated from a soil-derived Streptomyces sp. by Capon in 2014. spiro-Oxanthromicin inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells (IC50 27...

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Securinine

Securinine is a tetracyclic alkaloid isolated from the roots of Securinega suffruticosa with an unusual structure in which the piperidine ring has a skewed boat form and the diene is not coplanar. Securinine inhibits [3H]GABA binding to rat brain...

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Sartorypyrone D

Sartorypyrone D is a meroterpenoid produced by Neosartorya fischeri FO-5897 and isolated by Omura and co-workers at the Kitasato Institute, Japan, in 2015. Sartorypyrone D is a potent inhibitor of NADH-fumarate reductase and NADH oxidase with IC50 OF 1.7...

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Rubiginone D2

Rubiginone D2 was isolated from a Streptomyces sp. by Zeeck and co-workers, University of Gottingen, Germany in 2000. Rubiginone D2 is an angucycline, an angular tetracyclic benzanthracene core containing a highly oxygenated A ring. Rubiginone D2 is a...

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