Antibacterials

Pyrenophorin

Pyrenophorin, the diketone analogue of pyrenophorol, was first reported as a metabolite of the oat pathogen Pyrenophora avenae showing cytostatic properties. Pyrenophorin is a simple macrocyclic dilactone with phytotoxic and antifungal activity...

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Psychotridine

Psychotridine is the main component of an alkaloid complex isolated from Psychotria beccaroides by Lamberton and colleagues (CSIRO, Australia) in 1974. Psychotridine is structurally related to hodgkinsine. The structure of psychotridine was revised in...

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Protoporphyrin Disodium

Protoporphyrin Disodium is the disodium salt of Protoporphyrin (syn: Protoporphyrin IX, PPIX), a heterocyclic organic compound and the final intermediate in heme biosynthesis.  Present in all living cells, it serves as a substrate for ferrochelatase...

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Plumbagin

Plumbagin is a yellow-orange pigment isolated from Plumbagin and other plant species. Research into Plumbagin dates back to the early 1800s, with its synthesis reported in 1936. Plumbagin has a broad biological activity, including bactericidal,...

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Piliformic Acid

Piliformic Acid is produced by fungi including Xylaria sp. Piliformic acid has mild inhibitory activity against Propionobacterium acnes, inhibiting the P. acnes-induced pro-inflammatory cytokines production in THP-1 cells. Piliformic acid is active...

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Pikromycin

Pikromycin was the first macrolide antibiotic, isolated in 1951 by the German researchers Brockmann and co-workers from Streptomyces sp. Its structure as a 14-membered lactone linked to D-desosamine was confirmed in 1957. Pikromycin is synthesized...

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Phomopsinamine

Phomopsinamine is a potent mycotoxin produced by the fungus, Phomopsis leptostromiformis. Phomopsinamine is formed by hydrolysis of the dicarboxylic acid of phomopsin A. The phomopsins cause lupinosis in livestock fed infected lupins. Phomopsinamine is a...

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Pepstatin A

Pepstatin A, a pentapeptide isolated from Streptomyces sp. is a strong inhibitor of aspartyl proteases such as pepsin, cathepsin D, and renin. Pepstatin is active against HIV-1 and Plasmodium falciparum. HIV-infected H9 cells...

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Pentalenic acid

Pentalenic acid has been isolated from many Streptomyces sp. as a co-metabolite of the sesquiterpenoid antibiotic pentalenolactone and related natural products. Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family...

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Penipurdin A

Penipurdin A was first reported as an orange-red anthraquinone produced by soil-derived Penicillium purpurogenum by Li and co-workers from the Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong, China in 2015...

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Palmarumycin C3

The palmarumycins are fungal metabolites isolated from Coniothyrium and Sphaeropsidales sp. with antifungal, antibacterial, antitumor and herbicidal properties. Palmarumycin C3 is a yellow-green pigment which inhibits Ras farnesyl-protein...

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Pactamycin

Pactamycin (syn: Pactacin) is a unique type of highly-substituted aminocyclitol produced by Streptomyces sp. which is a potent inhibitor of translation in eukaryotes, bacteria and archaea, active against Gram-positive and Gram-negative bacteria. ...

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