Antibacterials

Erythromycin 2'-propionate

Erythromycin 2-propionate is the propionic acid ester precursor of erythromycin, the 14-membered macrocyclic lactone produced by Streptomyces erythreus. Erythromycin propionate displays an MIC of 0.01 – 0.05 ug/mL when tested against Micrococcus...

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Epirubicin Hydrochloride

Epirubicin is the 4'-epi-isomer of the antitumor agent, doxorubicin. Epirubicin acts by inhibiting topoisomerase II resulting in DNA double strand breaks. The anthracyclines also act by evicing histone from open chromatin, deregulating the...

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Emeguisin A

Emeguisin A was first isolated from the fungus Emericella unguis by Yamakazaki and coworkers from Hoshi University, Japan in 1988. Emeguisin A exhibits potent antibacterial activity against Staphylococcus aureusincludin methicillin-​resistant strains, as...

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Echinosporin

Oligomycins and pamamycin homologs impair motility and induce lysis of zoospores of the grapevine downy mildew pathogen, Plasmopara viticola. Dame Z.T. et al. FEMS Microbiol Lett. 2016, 363, 167. Molecular Formula  C10H9NO5 References Cui...

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DL-2,6-Diaminopimelic Acid

DL-2,6-Diaminopimelic Acid is a stereoisomer of mesodiaminopimelic acid (meso-DAP), a constituent of the peptidoglycans present in the cell walls of algae and most bacteria. DL-Diaminopimelic Acid is found in the cell wall of some actinomycetes,...

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Cryptopleurine

Cryptopleurine is a phenanthroquinolizidine secondary metabolite from Cryptocarya pleurosperma first reported by de la Lande, Melbourne University, Australia in 1948 and its structure revised in 1954. Cryptopleurine has antifungal activity via inhibition...

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Creatinine

Creatinine is an endogenous breakdown product of creatine used to measure kidney function. Creatinine has antibacterial activity against Gram-positive and Gram-negative bacteria, including resistant strains. Creatinine may impact the ability of immune...

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Conglobatin B

Conglobatin B was isolated from a previously unreported Streptomyces strain, phylogenetically distinct from the reported conglobatin A producer, Streptomyces conglobatus. Conglobatins B and C diverge from conglobatin through differing...

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Circumdatin A

Circumdatin A, produced by Aspergillus sp., was first reported in 1999 by Rahbaek and colleagues, University of Copenhagen, Denmark. The structure of circumdatin A was revised as a unique oxepine in 2008 using X-ray crystallography. Lack of availability...

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Cinnabarinic acid

Cinnabarinic acid is an endogenous kynurenine metabolite formed from oxidative dimerization of 3-​hydroxyanthranilic acid and transamination of 3-​hydroxykynurenine. Cinnabarinic acid activates glutamate receptors by interacting with residues of the...

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Chaetoviridin A

Chaetoviridin A, an azaphilone isolated from Chaetomium sp., is a potent antifungal against plant pathogenic fungi in vitro and in vivo, suppressing the development of rice blast and wheat leaf rust by over 80​% at a concentration of 62.5 mcg/mL...

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Chaetoglobosin A

Chaetoglobosin A is a mycotoxin of the cytochalasin class produced by Chaetonium globosum. Like other cytochalasins, chaetoglobosin A has a broad biological profile with antitumor, nematocidal, antifungal, antibiotic and antiamebic activity...

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