Insects and Parasites

Avermectin B1b

Avermectin B1b is the minor component (<20%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1b contains an isopropyl residue in the 25-position. In vitro and in vivo studies have shown this...

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Nemadectin

Nemadectin is a natural substance with broad-spectrum endectocidal, nematicidal and insecticidal activity. It is a macrocyclic lactone that is structurally similar to milbemycin and avermectin antibiotics, differing by the unsaturated side-chain...

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Ophiobolin C

Ophiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris.Ophiobolin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.Mechanism of ActionOphiobolin C inhibits human...

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epi-Avermectin B1a

epi-Avermectin B1a is a base-catalysed intermediate in the decomposition of Avermectin B1a. Epi-Avermectin B1a is formed by epimerisation at the 2-position which ultimately rearranges irreversibly to the isomeric alkene analog, Delta2-avermectin B1a...

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Enniatin B1

Enniatins are a family of depsipeptide ionophores produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...

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Ivermectin B1a monosaccharide

Ivermectin monosaccharide is a semi-synthetic produced by selective hydrolysis of the terminal saccharide unit of ivermectin. Ivermectin monosaccharide is a potent inhibitor of nematode larval development, but is devoid of paralytic activity. The...

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Doramectin Monosaccharide

Doramectin Monosaccharide is an acid degradation product produced by selective hydrolysis of the terminal saccharide unit of doramectin. Doramectin Monosaccharide is a potent inhibitor of nematode larval development, but is devoid of paralytic activity...

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Anhydroophiobolin A

3-Anhydroophiobolin A is the dehydrated analogue of ophiobolin A and is a major member of the ophiobolin complex of phytotoxic metabolites produced by many species of the genus Bipolaris. Like all ophiobolins, 3-anhydroophiobolin A possesses a broad...

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Eprinomectin B1a

Eprinomectin B1a is a semi-synthetic analogue of avermectin B1a prepared by oxidation of the 4''-hydroxy moiety and reductive amination followed by acetylation. Eprinomectin B1a is the major component (>90%) of the commercial product for endo- and...

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Moxidectin

Moxidectin is a semi-synthetic antiparasitic agent belonging to the the macrocyclic lactone (LC) family, and milbemycin sub-family. It is derived from nemadectin by selective oxidation followed by methyloximation. Nemadectin is a fermentation product of...

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Emamectin B1a

Emamectin B1a is a semi-synthetic 4"-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4"-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin...

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Neoaureothin

Neoaureothin is an unusual chain-extended analogue of aureothin. Neoaureothin was first reported as a co-metabolite of neoantimycin in Streptomyces orinoci. Neoaureothin has anti-HIV and antifungal activity. Recent investigations have identified two...

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