Teicoplanin A3-1 is a minor polar analog of a family of lipoglycopeptides produced by Actinoplanes teichomyceticus. Teicoplanins possess potent broad-spectrum antibiotic activity against Gram-positive bacteria, including MRSA and E. faecalis. Teicoplanin A3-1 is the common degradation product of Teicoplanins A2-1 to 5, resulting from cleavage of the lipoaminoglycoside substituents.
Teicoplanin A3-1 is soluble in ethanol, methanol, DMF and DMSO.
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Molecular Formula | C72H68Cl2N8O28 |
Microbiology Applications |
Teicoplanin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
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References | Parenti F et al (1978) Teichomycins, new antibiotics from Actinoplanes teichomyceticus nov. sp. J. Antibiotics 31:276 Goldstein BP et al (1994) Glycopeptide antibiotics. Edited by Nagarajan R. Dekker New York. pp. 273 |