SKU: T126  / 
    CAS Number: 560130-42-9

    Telavancin Hydrochloride

    ¥16,750.83 - ¥82,158.85

    Telavancin Hydrochloride is the hydrochloride salt of Telavancin, a lipoglycopeptide antimicrobial that has bactericidal activity against Gram-positive bacteria including MRSA.  It was derived from Vancomycin, and has superior in vitro activity against glycopeptide-susceptible organisms. 

    Telavancin Hydrochloride is very soluble in water.

    Mechanism of Action Telavancin inhibits the synthesis of bacterial cell walls by binding to the D-Ala-D-Ala terminus of the peptidoglycan in the growing cell wall. It also disrupts bacterial cell membrane potential and permeability since the lipophilic moiety of the compound may interact with the lipid bilayer in the membrane.
    Spectrum Effective against Gram-positive bacteria such as MRSA, VISA and hVISA strains of S. aureus.
    Microbiology Applications Telavancin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.

    Representative concentration ranges include:
    • Staphyloccus aureus (methicillin-resistant) 0.06-0.5 μg/ml
    • Streptococcus pneumonia (penicillin-resistant) 0.015-0.03 μg/ml
    For additional MIC data, click here. 
    Molecular Formula C80H107Cl3N11O27P
    References

    Damodaran SE and Madhan S (2011) Telavancin: A novel lipoglycopeptide antibiotic. J. Pharmacol Pharmacother. 2(2):135-137 PMID 21772784

    Higgins DL (2005) Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillinr-resistant Staphylococcus aureus. Antimicrob Agents Chemother 49 (3):1127-1134

    Jansen WT, Verel A, Verhoef A and Milatovic D (2007) In vitro activity of Telavancin against Gram-positive clinical isolates recently obtained in Europe. Antimicrob. Agents Chemother. 51:3420–3424 PMID 17606689

    Ruggero MA, Peaper DR and Topal JE (2015) Telavancin for refractory methicillin-resistant Staphylooccus aureus bacteremia and infective endocarditis. Infect. Dis. (Lond) 47(6):379-384 PMID 25746601