Choline Chloride is an essential nutrient commonly grouped with the B complex vitamins that plays key roles in many biological processes. Choline is found in sphingomyeline and lecithin. It is a precursor to acetylcholine. It plays a role in methyl group metabolism and can be used as a standard in methionine and choline metabolism.
Choline Chloride is soluble in aqueous solution.
Mechanism of Action | Choline serves as a precursor component to two major cell membrane components: phosphatidylcholine and sphingomyelin. In addition, choline also functions as a methyl group donor to several different substrates. |
Microbiology Applications | Because of its role in normal cellular processes, Choline Chloride can be used as a cell culture media supplement. |
Eukaryotic Cell Culture Applications | Choline was added to culture medium of in vitro-produced embryos to see if it altered the phenotype of blastocysts. Choline was found to alter the phenotype of preimplantation bovine embryos produced in vitro. Choline chlorine can act in a concentraiton-dependent manner to alter development, gene expression, and DNA methylation (ref). |
Plant Biology | Choline chloride based solvents can be used in extraction media for extracting phenolic compounds. |
Impurities | Arsenic: ≤2ppm Lead: ≤0.3ppm Limit of Amines: ≤0.001% Individual Impurity: ≤0.3% Total Impurities: ≤2.0% Organic Volatile Impurities: Meets requirements |
References |
Brailoiu E et al (2019) Choline is an intracellular messenger linking extracellular stimuli to IP3-evoked Ca2+ signals through sigma-1 receptors. Cell Rep. 26(2):P330-337 Estrada-Cortés E et al (2020) Effects of choline on the phenotype of the cultured bovine preimplantation embryo. J. Dairy Sci. 103(11):10784-10796 PMID 32896407 Razboršek M et al (2020) Choline Chloride based natural deep eutectic solvents as extraction media for extracting phenolic compounds from chokeberry (Aronia Melanocarpa). Molecules. 25(7):1619 PMID 32244757 Xu H et al (2021) Comprehensive analysis of important parameters of choline chloride-based deep eutectic solvent pretreatment of lignocellulosic biomass. Bioresour Technol 319:124209 |