Cloxacillin Sodium is a narrow-spectrum β-lactam antibiotic of the penicillin class. Cloxacillin Sodium is sparingly soluble in aqueous solution.
| Spectrum | Cloxacillin targets primarily Gram-positive bacteria, especially β-lactamase producing Staphylococci. |
| Microbiology Applications |
Cloxacillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Staphylococcus aureus 0.2 µg/mL – 3.13 µg/mL For a representative list of Cloxicillin MIC values, click here. |
| Molecular Formula |
C19H17ClN3NaO5S · H2O |
| References |
Guzmán F (2008) Beta-Lactams antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology Pitout JD, Sanders CC, Sanders WE Jr (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am. J. Med 103:51 |
| MIC |
Diplococcus pneumoniae| 0.005 - 0.4 || Haemophilus influenzae| 12.5 - 50 || |
