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Detailed Description
Molecular Formula: C17H25N3O5S • Na2CO3
Molecular Weight: 466.46
Mechanism of Action: β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, Meropenem is highly resistant to the degradative effects of β-lactamases.
Storage Conditions: 2-8°C
Tariff Code: 2941.90.5000
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Specifications
Form: Powder
Appearance: White or almost white powder
pH: 7.3 - 8.3
Assay: (Dried basis, Meropenem) Not less than 78.0%
Residue On Ignition: Not more than 0.1%
Heavy Metals: Not more than 10ppm
Loss on Drying: 9.0% - 12.0%
Identification: Passes test
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Technical Data
Solubility: Very soluble in water (112 mg/ml)
Content of Sodium: 7.3 - 10.9%
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References
References:
Guzmán F(2008) Beta lactams antibiotics (penicillins and cephalosporins) mechanism of action. Med. Pharmacol. Pharmacology Corner, 29 Nov. 2008
Ogawa Ya and Mii M (2007) Meropenem and moxalactam: Novel B-lactam antibiotics for efficient Agrobacterium-mediated transformation. 172(3):564-572Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am J Med 103:51
Sjahril R and Masahiro Mii M (2006) High-efficiency Agrobacterium-mediated transformation of Phalaenopsis using Meropenem, a novel antibiotic to eliminate Agrobacterium. J. Hort. Sci and Biotechnol 8(3):458-464Yang Y, Bhachech N and Bush K (1995) Biochemical comparison of imipenem, Meropenem and biapenem: Permeability, binding to penicillin-binding proteins, and stability to hydrolysis by β-lactamases. J. Antimicrob. Chemother. 35(1):75-84
Meropenem with Sodium Carbonate is a salt form of Meropenem, a β-lactam antibiotic in the carbapenem class, which targets the bacterial cell wall. Meropenem has found utility against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae that are resistant to many β-lactam antibiotics and certain cephalosporins. Meropenem with Sodium Carbonate is very soluble in water.
We also offer:
- Meropenem, USP (M002)
Molecular Formula: C17H25N3O5S • Na2CO3
Molecular Weight: 466.46
Mechanism of Action: β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, Meropenem is highly resistant to the degradative effects of β-lactamases.
Storage Conditions: 2-8°C
Tariff Code: 2941.90.5000
Form: Powder
Appearance: White or almost white powder
pH: 7.3 - 8.3
Assay: (Dried basis, Meropenem) Not less than 78.0%
Residue On Ignition: Not more than 0.1%
Heavy Metals: Not more than 10ppm
Loss on Drying: 9.0% - 12.0%
Identification: Passes test
Solubility: Very soluble in water (112 mg/ml)
Content of Sodium: 7.3 - 10.9%
References:
Guzmán F(2008) Beta lactams antibiotics (penicillins and cephalosporins) mechanism of action. Med. Pharmacol. Pharmacology Corner, 29 Nov. 2008
Ogawa Ya and Mii M (2007) Meropenem and moxalactam: Novel B-lactam antibiotics for efficient Agrobacterium-mediated transformation. 172(3):564-572
Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am J Med 103:51
Sjahril R and Masahiro Mii M (2006) High-efficiency Agrobacterium-mediated transformation of Phalaenopsis using Meropenem, a novel antibiotic to eliminate Agrobacterium. J. Hort. Sci and Biotechnol 8(3):458-464
Yang Y, Bhachech N and Bush K (1995) Biochemical comparison of imipenem, Meropenem and biapenem: Permeability, binding to penicillin-binding proteins, and stability to hydrolysis by β-lactamases. J. Antimicrob. Chemother. 35(1):75-84
