SKU: P056  / 
    CAS Number: 7239-48-7 (free base)

    Polymyxin E2 Sulfate, EvoPure®


    Polymyxin E2 Sulfate, EvoPure® (syn: Colistin B) is one of the two major components of Polymyxin E (Colistin). Polymyxin E1 and E2 are structurally similar and differ only by a fatty acid group at the N-terminus. Polymyxin E1 contains 6-methyloctanoic acid and Polymyxin E2 (Colistin B) contains 6-methylheptanoic acid. Together, Polymyxin E1 and E2 comprise approximately 85% of Polymyxin E; however, 13 different Polymyxin E components have been indentified.

    We also offer:

    • Polymyxin B Sulfate, USP (P007)
    • Polymyxin B1 Sulfate, EvoPure® (P037)
    • Polymyxin B1-I Sulfate, EvoPure® (P038)
    • Polymyxin B2 Sulfate, EvoPure® (P039)
    • Polymyxin B3 Sulfate, EvoPure® (P040)
    • Polymyxin B6 Sulfate, EvoPure® (P054)
    • Polymyxin E1 Sulfate, EvoPure® (P055)
    • Polymyxin E2 Sulfate, EvoPure® (P056)

    EvoPure® products are purified single antibiotic fractions, most are >99% pure. Highly pure EvoPure® Polymyxin products can be used to analyze the specific effects of individual Polymyxin B fractions.

    Mechanism of Action Polymyxin E has a bactericidal effect on Gram-negative bacteria by interacting with and displacing essential ions in the lipopolysaccharide (LPS) outer cell wall leading to increased permeability and eventually lysis and death of the cell.
    Spectrum Polymyxin E is used primarily against Gram-negative bacteria including Pseudomonas aeruginosa, Klebsiella pneumoniae, and multi-drug resistant Enterobacteriaceae,
    Microbiology Applications Polymyxin E1 and E2 (Colistin A and B, respectively) can be used individually to study and compare in vitro antimicrobial activity with colistin (polymyxin E complex) or other polymyxins.
    Molecular Formula C52H98N16O13 · xH2SO4 (lot specific)

    Bergen, PJ, Craig JL, Rayner CR and Nation RL (2006)  Colistin methanesulfonate is an inactive prodrug of Colistin against Pseudomonas aeruginosa. Antimicob. Agents Chemother.  50(6):1953-1958  PMID 16723551

    Decolin D, Leroy P, Nicolas A and Archimbault P (2013)  Hyphenated liquid chromatographic method for the determination of colistin residues in bovine tissues.  J. Chromatogr. Sci. 35(12):557-564  PMID 9397540

    Falagas ME and Kasiakou SF (2005)  Colistin: The revival of polymyxins for the management of multidrug-resistant Gram-negative bacterial infections.  Clin. Infect. Dis.40(9):1333-1341  PMID 15825037

    Leifert C, Ritchie JY and Waites WM (1991)  Contaminants of plant-tissue and cell cultures. World J.  Microbiol. and Biotechnol. 7:452-469  PMID 24425131

    Li J and Nation RL (2006) Comment On: Pharmacokinetics of inhaled colistin in patients with cystic fibrosis. J. Antimicrob. Chemother. 58(1):222-223  PMID 16641116

    Muellerr MJ, Brodschelm W, Spannagl E and Zenk MH (1993)  Signaling in the elicitation process is mediated through the octadecanoid pathway leading to jasmonic acid.  Proc. Natl. Acad. Sci. USA 90(16):7490-7494  PMID 11607420