Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Tenofovir alafenamide is an antiretroviral developed by Gilead and the anti-HIV activity was reported in 1993. It is an investigational precursor to Tenovor, a nucleotide reverse transcriptase inhibitor. Tenofovir alafenamide is...
Anguinomycin A is a natural polyketide and analog of Leptomycin B, an inhibitor of protein nuclear export. It is isolated from Streptomyces spp., and displays anti-cancer activity. Anguinomycins B, C and D are also members of the Leptomycin...
Kazusamycin A is a minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin B, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and biological...
Leptomycin B is the dominant member of the Leptomycin class, secondary metabolites isolated from selected Streptomyces strains. It is a bioactive small molecule with antifungal and antibacterial activity. It is a nuclear export inhibitor,...
Miconazole Nitrate is the nitrate salt of Miconazole, an imidazole antimycotic compound patented in 1968 (Janssen Pharmaceutica). It targets the fungi that cause tinea (ringworm) and athlete’s foot. It inhibits ergosterol synthesis, and...
Anidulafungin is a semi-synthetic echinocandin derivative and antifungal effective against Candida spp. Anidulafungin inhibits fungal cell wall synthesis. It is useful in pharmacotherapy and cell culture research applications. It is...
Amphotericin B, USP (syn: Fungizone) is a polyene macrolide aminoglycoside broad-spectrum antimycotic. This bioactive natural product was isolated from soil collected from Orinoco River (Venezuela) in 1955 and identified as Streptomyces nodosus by...
Midecamycin is an naturally occurring, broad-spectrum acetoxy-substituted macrolide antibiotic similar in structure to erythromycin. An acetoxy group is substituted on position 9 of the 16-membered ring and on position 4 of the terminal sugar...
Clotrimazole is a broad-spectrum antifungal belonging to the imidazole subclass of azole compounds. These compounds interfere with the biosynthesis of ergosterol, a major membrane component of the fungal cytoplasmic membrane. Clotrimazole was discovered...
4-CPPU (CPPU) is a highly active plant growth regulator of the cytokine class that increases chlorophyll biosynthesis, cell division and cell expansion. It can increase fruit set and fruit enlargement and promote somatic embryogenesis. It works...
Florfenicol is a fluorinated synthetic analog of Thiamphenicol, belonging to the amphenicol class which also contains Choramphenicol. It is metabolized to Florfenicol Amine. The compound is a highly potent inhibitor of bacterial protein...
Metronidazole is a bioactive small molecule and broad-spectrum nitromidazole antibiotic used against anaerobic bacteria and parasites. The hydroxy metabolite, 1-(2-hydroxy-ethyl)-2-hydroxy methyl-5-nitroimidazole is considered the major active...
