Inhibitor

Terpendole I

Terpendole I is a polar analog of a rare family of indolediterpenes isolated from Albophoma yamanashiensis, first reported by Omura and colleagues at the Kitasato Institute, Japan in 1995. Terpendole I is a weak inhibitor of ACAT (acylCoA:cholesterol...

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Voacamine

Voacamine is an indole alkaloid derived from members of the Voacanga species, indigenous to Africa. In the Pacific region,voacamine was successfully isolated from the small tree, Voacanga papuana, indigenous to New Guinea by Ritchie and Taylor,...

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Levodropropizine

Levodropropizine has anti-allergic properties and inhibits the histamine receptor. It acts as a peripheral antitussive agent. Mechanism of Action Levodropropizine has affinity for H1-histaminic and alpha-adrenergic receptors. Levodropropizine has a...

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Xanthyletin

Xanthyletin, a dimethylpyranocoumarin structurally related to psoralen, is the active principal of Luvanga scandens widely used in Hindu medicine. Xanthyletin was isolated from the New Guinea tree, Flindersia pimenteliana, by Taylor and Ritchie,...

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Emodepside

Emodepside is an anthelmintic, belonging to the cyclooctadepsipeptides class. It is effective against gastrointestinal nematodes. The starting material of Emodepside is a natural metabolite of the fungus Mycelia sterilia, which inhabits the leaves of...

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Drimendiol

Drimendiol is the sesquiterpene dialcohol of polygodial, found in a number of plant species native to Australia and NewZealand. More recently, drimendiol was prepared from polygodial isolated from Tasmannia lanceolata by Smith and colleagues at the...

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Levofloxacin Hydrochloride

Levofloxacin Hydrochloride is the hydrochloride salt of Levofloxacin.  It is a broad-spectrum fluoroquinolone antibiotic and the optical S-(-) isomer of Ofloxacin. The compound is a DNA gyrase inhibitor, and has been shown to inhibit topoisomerase...

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2'-C-Methylcytidine

2’-C-Methylcytidine (syn: 2CMC) is a viral replication inhibitor, shown to be active against multiple viruses including hepatitis C virus (HCV), inhibiting the HCV NS5B RNA polymerase.  It is also used against other viruses including Norwalk,...

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Nalidixic Acid Sodium, CulturePure®

Nalidixic Acid Sodium, CulturePure® is a synthetic 1,8-naphthyridone antibiotic similar in structure and mechanism to quinolones, the commercial preparation of which was developed by Sanofi Aventis.  The product is commonly used as a selective...

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Sulfamethizole

Sulfamethizole is a broad-spectrum sulfathiazole antibacterial of the Sulfonamide class, used for the bacteria causing urinary tract infections.  Acting as a synthetic analog of  para-aminobenzoic acid (PABA), it competitively inhibits this...

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Oseltamivir Phosphate

Oseltamivir Phosphate is an inhibitor of influenza viral neuraminidase.  It is also an antiviral used against influenza A and B.  Oseltamivir was discovered at Gilead in 1997 using shikimic acid as a starting point for synthesis.  The...

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Posaconazole

Posaconazole is a synthetic, broad-spectrum, second generation triazole with antifungal activity. It has potent in vitro and in vivo trypanocidal activity. It was discovered by Schering-Plough and it is a structural analog of itraconazole.  It has...

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