Antibacterials

Alternariol monomethylether

Alternariol monomethylether was first reported by Raistrick and colleagues in 1953. Alternariol and its monomethyl ether analogue occur in mycelium of Alternaria tenuis responsible for alternaria cone disorder in hops and fruit spot on papaya (Carica...

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Actinonin

Actinonin is a metabolite of Streptomyces roseoplallidus and other Streptomyces species, first reported in Nature in 1962. Actinonin is a bacteriostatic agent with activity against Gram-positive and fastidious Gram-negative microorganisms. Actinonin...

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Aclarubicin

Aclarubicin (aclacinomycin A) is an anthracycline and topoisomerase II inhibitor that has been clinically tested against haematologic and solid tumors. Aclarubicin stabilizes topoisomerase I cleavage. Aclarubicin accumulates efficiently in the...

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Acivicin

Acivicin is a chlorinated amino acid originally isolated from Streptomyces sviceus that inhibits glutmate metabolism. It has antifungal, antitumor and antileishmanial properties. Acivicin competitively inhibits amidophosphoribosyl-transferase, CTP...

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Acetomycin

Acetomycin, a γ-butyrolactone isolated from Streptomyces ramulosus, was first reported in 1958 by Ettlinger et al. at ETH Zurich. Acetomycin is potently active in vitro against HCT-8 human colon adenocarcinoma cells and L1210 murine leukemia cells...

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Acadesine

Acadesine was originally identified as a metabolite of Bacillus species and was shown to accumulate in the culture medium of E. coli under sulphonamide stasis. Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine. Ithas...

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Floramultine

Floramultine was first isolated from Kreysigia multiflora, a member of the Liliacaeae family, in 1960 by Badger and Bradbury, University of Adelaide, Australia. The absolute configuration of (-)-floramultine was later published by Lamberton and...

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5-Methoxycanthinone

5-Methoxycanthinone is a β-carboline first isolated from the Australian Rutaceae Pentaceras Australis Hook by Price and co-workers at the CSIRO, Australia in 1952. 5-Methoxycanthinone is a modest inhibitor of a panel of the human tumor cell lines:...

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4'-Acetylchrysomycin B

4’-Acetylchrysomycin B and its co-metabolite, 4’-acetylchrysomycin A, were isolated during a screen for antitumor agents. Acetylation of chyrsomycin B increase cytotoxicity. Acetylchyrsomycins are active against Gram-positive bacteria,...

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4'-Acetylchrysomycin C

4'-Acetylchrysomycin C is a methylated analogue of 4'-acetylchrysomycin A. To date there are no reports of the biological activity of 4-acetylchrysomycin C in the literature. Molecular Formula C30H32O10 References Wada S et al (2017) ...

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3-Hydroxy-L-tyrosine methyl ester

3-Hydroxy-L-tyrosine methyl ester (melevodopa, L-dopa methyl ester) is a prodrug of levodopa used for the treatment of Parkinson’s disease. L-​DOPA methyl ester is a potent competitive antagonist for the action of L-​DOPA...

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3-Acetyldeoxynivalenol

3-Acetyldeoxynivalenol is a trichothecene mycotoxin produced by Fusarium species, exhibiting dose-dependent reduction of lymphocyte proliferation in mitogen-induced blastogenesis, albeit less potently than deoxynivalenol. In a comparative study of...

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