Antibacterials

Descarbamylnovobiocin

Descarbamylnovobiocin is a member of the novobiocin aminocoumarin antibiotic family found as a minor co-metabolite ofnovobiocin fermentation and produced as an alkaline degradation product. Like novobiocin, Descarbamylnovobiocin is aninhibitor of the...

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Dihydronovobiocin

Dihydronovobiocin is a semi-synthetic member of the novobiocin aminocoumarin antibiotic family prepared by reduction of the prenyl double bond and published in 1956. Dihydronovobiocin is an inhibitor of the bacterial type II topoisomerase, DNA gyrase...

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Levofloxacin Hydrochloride

Levofloxacin Hydrochloride is the hydrochloride salt of Levofloxacin.  It is a broad-spectrum fluoroquinolone antibiotic and the optical S-(-) isomer of Ofloxacin. The compound is a DNA gyrase inhibitor, and has been shown to inhibit topoisomerase...

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Isepamicin Sulfate

Isepamicin sulfate is an aminoglycoside antibiotic derived from gentamicin B.Mechanism of ActionSimilar to other aminoglycosides, isepamicin sulfate binds to the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty...

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Sitafloxacin Hydrate

Sitafloxacin Hydrate is a broad-spectrum fluoroquinoline antibiotic that is particularly active against Gram-positive bacteria such as a pneumococci. Mechanism of Action Sitafloxacin has been shown to have a dual targeted mechanism of action. Other...

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Anacardic Acid

Anacardic acid is a histone acetyltransferase (HAT) inhibitor that is derived from cashew shells. Anacardic acid is associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. Anacardic acid is a common inhibitor of several...

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Ceftaroline Fosamil

Ceftaroline Fosamil is a fifth-generation cephalosporin, a broad-spectrum β-lactam active against MRSA and respiratory pathogens.  It carries the trade name Teflaro (US) or Zinforo i(Europe).  It can be used against the bacteria causing...

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Nitrofurantoin Sodium

Nitrofurantoin Sodium is the sodium salt of Nitrofurantoin, a broad-spectrum nitrofuran antibiotic that is used as a substrate for bacterial glycoprotein nitrofuran reductase. It is bacteriostatic against Gram-positive and Gram-negative bacteria. The...

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Framycetin Sulfate

Framycetin Sulfate (syn: Neomycin B Sulfate) is the sulfate salt form of Neomycin, a broad-spectrum aminoglycoside antibiotic derived from Streptomyces fradiae.  Neomycin B is ~ 65% more active than its stereoisomer, Neomycin C, and ~ 90% more...

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Flomoxef Sodium

Flomoxef Sodium is a β-lactam inhibitor and member of the oxacephem family and exhibits antibiotic properties.  It has been used for respiratory infections and bone diseases (ie osteoporosis).  It was synthesized in 1982 by Shionogi &...

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Temocillin Disodium

Temocillin Disodium is the salt of Temocillin, a semisynthetic, β-­lactamase-resistant carboxypenicillin antimicrobial. Temocillin is the 6-alpha-methoxy derivative of ticarcillin.  Temocillin is is used as an alternative to carbapenems and...

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Pexiganan acetate

Pexiganan is an antimicrobial peptide (AMP) that is effective against a broad spectrum of bacteria including aerobic and anaerobic, gram-positive and gram-negative. Bacterial resistance to pexiganan is very unlikely to develop.Mechanism of...

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