Antiparasitics

Caerulomycin

Caerulomycin is a rare and unusual antibiotic containing a core 2, 2'-bispyridyl with an oxime substituent, produced by a strain of Streptomyces caeruleus isolated in Canada in 1959. Caerulomycin is active against fungi and some protozoans, and is weakly...

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Aureothricin

Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Aureothricin is a more hydrophobic...

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Anhydroophiobolin A

3-Anhydroophiobolin A is the dehydrated analogue of ophiobolin A and is a major member of the ophiobolin complex of phytotoxic metabolites produced by many species of the genus Bipolaris. Like all ophiobolins, 3-anhydroophiobolin A possesses a broad...

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Trichostatin C

Trichostatin C is the first example of a glucopyranosyl hydroxamate from nature. The conjugation may act to protect the less stable N-OH group of Trichostatin A. Trichostatin C displays antifungal, antiprotozoan and antitumor activity, albeit less potent...

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Eprinomectin B1a

Eprinomectin B1a is a semi-synthetic analogue of avermectin B1a prepared by oxidation of the 4''-hydroxy moiety and reductive amination followed by acetylation. Eprinomectin B1a is the major component (>90%) of the commercial product for endo- and...

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Moxidectin

Moxidectin is a semi-synthetic antiparasitic agent belonging to the the macrocyclic lactone (LC) family, and milbemycin sub-family. It is derived from nemadectin by selective oxidation followed by methyloximation. Nemadectin is a fermentation product of...

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Emamectin B1a

Emamectin B1a is a semi-synthetic 4"-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4"-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin...

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Eprinomectin

Eprinomectin is a mixture of eprinomectins B1a and B1b in a 9:1 ratio, produced from a mixture of avermectin B1a and B1b. Eprinomectin is used commercially as a topical endectocide (insecticide, miticide and nematocide) for cattle, including lactating...

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Antimycin A1

Antimycin A1 is the most hydrophobic of the four analogs of the Antimycin A complex. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes.Antimycin...

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Spiramycin

Spiramycin is a broad-spectrum 16-membered ring macrolide antibiotic composed of a mixture of spiramycin I, II, and III.  Spiramycin was first isolated by PINNERT-SINDICO in 1954 from Streptomyces ambofaciens.  Spiramycin is a...

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Anhydroepiophiobolin A

Anhydroepiophiobolin A is a dehydrated analogue of ophiobolin epimerised at the C6 position. Anhydroepiophiobolin A is the major terminal degradation product of ophiobolin A and is co-produced with other ophiobolins in many Bipolaris species. Prior to...

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Brevicompanine B

Brevicompanine B is a diketopiperazine-related metabolite produced by Penicillium and Aspergillus species. Brevicompanine B is active against the malaria parasite, Plasmodium falciparum, and shows pronounced plant growth regulatory activity but is devoid...

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