Antiparasitics

Atovaquone

Atovaquone is a hydroxynaphthoquinone antimicrobial compound with antipneumocystic and anti-parasitic properties.Mechanism of ActionAtovaquone inhibits cytochrome bc1 of the electron transport system leading to failure of mitochondrial function...

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Elaiophylin

Elaiophylin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase and is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelmintic and...

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Cochlioquinone B

Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A which inhibits diacylglycerol...

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Artemisinin

Artemisinin is a sesquiterpene lactone compound with anti-malarial activity against cerebral malaria causing and drug-resistant strains of Plasmodium falciparum. Artemisinin and some of its derivatives have anti-tumor properties and are effective against...

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Oligomycin E

Oligomycin E (26-hydroxyoligomycin B) is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes. ...

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21-Hydroxyoligomycin A

21-Hydroxyoligomycin A is a rare member of the Oligomycin class, isolated as a co-metabolite of nemadectin, hence it was originally named Nemadectin omega. Only limited literature references are available. In-house testing suggests that...

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Oligomycin C

Oligomycin C is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic cytotoxicity...

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Tetracycline Hydrochloride, EP/USP

Tetracycline Hydrochloride, EP/USP (syn. Tetracycline HCl) is a light-sensitive bacteriostatic polyketide antibiotic frequently used in a wide range of in vitro cell culture applications. Tetracycline (achromycin) is a first-generation tetracycline...

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Oligomycin D

Oligomycin D (Rutamycin) is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic...

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Ophiobolin A

Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi.Ophiobolin A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.Mechanism of ActionOphiobolin A acts by inhibiting calmodulin...

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Artesunate

Artesunate is an anti-malarial drug and has been found to be effective against multidrug-resistant Plasmodium falciparum and P. vivax malaria. Artesunate has also been found to have anti-cancer activity against leukemia and colon cancer cell lines...

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Tetracycline, USP

Tetracycline, USP is a light-sensitive bacteriostatic polyketide antibiotic frequently used in a wide range of in-vitro cell culture applications. Tetracycline is a first-generation Tetracycline antibiotic and was first identified in 1953 by Chemist...

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