Antitumor

Oxozeaenol, (5E)-7-

(5E)-7-Oxozeaenol ("iso-LL Z1640-2") is a resorcylic acid lactone belonging to the Zearalenone class, recognised as a minor metabolite of the fungus, Drechslera portulacae. (5E)-7-Oxozeaenol was rediscovered as a major analog of a resorcylic acid lactone...

View Details

Polygodial Pyridazine

Polygodial Pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal,...

View Details

Penicinoline

Penicinoline is an unusual quinolinone alkaloid isolated from a mangrove endophytic Penicillium species by researchers at the Key Laboratory of Marine Drugs in collaboration with Syngenta and first reported in 2010. Penicinoline posseses broadspectrum...

View Details

Radicinol

Radicinol is a mycotoxin isolated from Curvularia lunata (syn. Cochliobolus lunata) by researchers at Nagoya University, Japan in 1977. Subsequently, Radicinol has been found as a secondary metabolite in a diverse range of plant pathogenic fungi. ...

View Details

Roccellic Acid

Roccellic Acid is a secondary metabolite and methyldodecylsuccinic acid isolated from lichen Roccella spp. over 150 years ago, with the structure fully elucidated by Akermark in 1962. Roccellic Acid is active against the oral bacteria, Streptococcus...

View Details

Salazinic Acid

Salazinic Acid is a depsidone lichen metabolite first reported over a 100 years ago and widely distributed across many lichen genera. Salazinic Acid is moderately active against Gram-positive bacteria and some Gram-negative bacteria (P. aeruginosa and S...

View Details

Strychnospermine

Strychnospermine is an alkaloid isolated by Ritchie et al. at the University of Sydney, Australia from the Australian native strychnine tree, Strychnos psilosperma, in 1950. There are no published reports of the biological activity of Strychnospermine. ...

View Details

Seselin

Seselin is a pyranocoumarin isolated from the fruits of Seseli indicum by Spath and colleagues in 1939. Seselin wassubsequently isolated from a number of fruits of diverse species, most notably star anise. More recently, Seselin has beenisolated...

View Details

Stachybotrysin B

Stachybotrysin B is an analogue of a complex of phenylspirodrimanes isolated from the fungus, Stachybotrys chartarum, by collaborating Chinese Key Research Institutes in 2017. Stachybotrysin B is active against HIV but is not cytotoxic.Stachybotrysins...

View Details

Sparsomycin

Sparsomycin is a nucleotide analogue produced by Streptomyces sparsogenes isolated by researchers at Upjohn (now Pfizer) in 1962. Sparsomycin binds to the 50S ribosomal subunit and inhibits protein synthesis via peptidyl transferase inhibition. ...

View Details

Sartorypyrone B

Sartorypyrone B is a pentacyclic meroterpenoid metabolite isolated from Aspergillus (syn. Neosartorya) species. Whilesartorypyrone B possesses no antibiotic activity against S. aureus, P. aeruginosa. B. subtilis and E. coli, it is nonethelessscapable of...

View Details

Streptimidone

Streptimidone (protomycin) is a glutarimide antibiotic isolated from Streptomyces spp. first reported in 1959. Streptimidone is active against a wide spectrum of fungi and protozoans, including Entamoeba hystolica in vitro and in vivo. Streptimidone also...

View Details