Antimicrobials

Chaetoglobosin A

Chaetoglobosin A is a mycotoxin of the cytochalasin class produced by Chaetonium globosum. Like other cytochalasins, chaetoglobosin A has a broad biological profile with antitumor, nematocidal, antifungal, antibiotic and antiamebic activity...

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Carbazomycin D

Carbazomycin D is a minor analogue of a family of carbazoles initially isolated from Streptomyces ehimense reported by researchers at Hiroshima University in 1987. Carbazomycin D was identified in a scaled and optimised fermentation of the same strain...

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Carbazomycin C

  Molecular Formula  C16H17NO3  

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Carbazomycin B

Carbazomycin B is the dominant analogue of a family of rare carbazoles initially isolated from an unidentified Streptomyces sp. by researchers at Hiroshima University in 1980. Carbazomycin B is a 5-lipoxygenase inhibitor and free radical scavenger...

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Carbazomycin A

Carbazomycin A is a minor metabolite of a family of rare carbazoles initially isolated from an unidentified Streptomyces sp. (subsequently identified as Streptomyces ehimense) by researchers at Hiroshima University in 1980. Carbazomycin A is active...

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Simvastatin Acid

Simvastatin acid is the active β-hydroxy acid metabolite of simvastatin formed in vivo. Simvastatin acid is a potent inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, an essential enzyme involved in the in vivo synthesis of...

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Penicolinate B

  Molecular Formula  C23H30N2O4  

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Burnettramic acid A aglycone

Burnettramic acid A and its aglycone are members of a new class of antibiotics from an Australian fungus Aspergillus burnettii.  The rare bolaamphiphilic scaffold consists of β-​d-​mannose linked to a pyrrolizidinedione unit via a 26-​carbon...

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Burnettramic acid A

Burnettramic acid A and its aglycone are members of a new class of antibiotics from an Australian fungus Aspergillus burnettii.  The rare bolaamphiphilic scaffold consists of β-​d-​mannose linked to a pyrrolizidinedione unit via a 26-​carbon...

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D-2-Aminoglutarimide

  Molecular Formula  C5H8N2O2  

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Beauveriolide III

Beauveriolides are 13-membered cyclodepsipeptides isolated from Beauveria sp. Beauveriolide III inhibits acyl-CoA:cholesterol acyltransferase (ACAT) to block the synthesis of cholesteryl ester, leading to a reduction of lipid droplets in macrophages...

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Beauveriolide I

Beauveriolides are 13-membered cyclodepsipeptides isolated from Beauveria sp.. Beauveriolides I and III inhibit macrophage acyl-CoA:cholesterol acyltransferase (ACAT) activity to block the synthesis of cholesteryl ester, leading to a reduction of lipid...

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