Antimicrobials

Nosiheptide

Nosiheptide is a broad-spectrum bicyclic thiopeptide antibiotic produced by several species of actinomycetes (ie Streptomyces) and was first reported by Japanese researchers in 1970. It has a prolonged post-antibiotic effect in both nosocomial and...

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Pentostatin

Pentostatin is a potent antitumor antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumor agent.Pentostatin is soluble in ethanol, methanol, DMF or DMSO...

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Deethylindanomycin

Deethylindanomycin (omomycin) is an unusual pyrrollic ionophore related to indanomycin, with activity against Gram positive bacteria and coccidia. Lack of availability has limited further investigation of this compound.Deethylindanomycin is soluble...

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LL-37 (human) Trifluoroacetate Salt

LL-37 (human) Trifluoroacetate Salt (LL-37) is a naturally-occuring antimicrobial peptide that is part of the innate host immune system. It is associated with the epidermis and protects the host from bacterial infection. LL-37 has also demonstrated a...

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Demeclocycline hydrochloride

Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for...

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Blasticidin A

Blasticidin A is a high molecular weight tetramic acid isolated from S. resistomycificus in 1955.  It has broad-spectrum antifungal and antibacterial activity.  Like many tetramic acids, Blasticidin A is isolated as the stable calcium...

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Curvularin

Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally...

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Nybomycin

Nybomycin is an unusual heterocyclic metabolite isolated from several Streptomyces species, first reported in 1961 from Streptomyces niveus. Nybomycin possesses antiviral and antibacterial activity. The spectrum of Nybomycin has not been extensively...

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Lasalocid

Lasalocid is a carboxylic polyether ionophore with potent antibacterial activity isolated from Streptomyces lasaliensis, first reported in 1951. It is a mixture of several related homologs(A, B, C, D and E) and  Lasalocid has been found to have...

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Lasalocid Sodium

Lasalocid Sodium is the salt form of Lasalocid, a carboxylic polyether ionophore. The compound has anticancer properties and antibacterial activity. Lasalocid is isolated from Streptomyces lasaliensis, first reported in 1951. It is also known as a...

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Asukamycin

Asukamycin is an unusual trienoic acid amide metabolite produced by Streptomyces nodosus, reported by Omura and colleagues at the Kitasato Institute, Japan, in 1976. Asukamycin belongs to the manumycin class that comprises two trienoic acid amides...

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Equisetin

The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors...

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