Antibacterials

Berkeleylactone E

Berkleylactone E is a major analog of a family of recently described macrolide antibiotics, isolated from a mixed fermentation of two Penicillium species. Berkleylactone E is active against Gram-positive bacteria, Candida albicans and Candida glabrata,...

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Berkeleylactone F

Berkleylactone F is a major analog of a family of recently described macrolide antibiotics, isolated from a mixed fermentation of two Penicillium species. Berkleylactone F is active against Gram-positive bacteria, Candida albicans and Candida glabrata,...

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Collinin

Collinin is a terpenylated coumarin isolated from Flindersia maculosa and other species by Ritchie and colleagues at Sydney University, Australia in 1954. Collinin possesses broad spectrum activity as an inhibitor of inflammation, collagenase and the...

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Chevalone E

Chevalone E is a minor analogue of the meroterpenoid chevalone family, isolated from Aspergillus similanensis by researchers in Portugal. Chevalone E is closely related to the aszonapyrones and sartorypyrones. Chevalone E is synergistic when used with...

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Evoxanthine

Evoxanthine is a furoacridone alkaloid isolated from Evodia xanthoxyloides by Hughes and Neill, University of Sydney, Australia in 1949. Evoxanthine is active against Gram-positive and Gram-negative bacteria, including E. coli, B. subtilis and M. luteus,...

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Galbinic Acid

Galbinic Acid (α-acetylsalazinic acid) is a depsidone isolated from the lichen, Usnea undulata. The structure of galbinic acid was elucidated by Elix, Australian National University in 1975. Galbinic Acid is moderately active against Gram-positive...

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Leoidin

Leoidin is a metabolite of the lichen, Lecanora gangleoides, first published in 1986 and recently reported as an inhibitor ofprotein synthesis in Pseudomonas aeruginosa. Leoidin is bacteriostatic, targeting PheRS. Leoidin is a weak inhibitor of human...

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Manumycin A

Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has...

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Novobiocic Acid

Novobiocic Acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic Acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic Acid exhibits little antibacterial...

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Pluviatolide

Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin were reported as metabolites of the vine, Aristolochia...

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Polygodial

Polygodial is a sesquiterpene dialdehyde first isolated from Persicaria hydropiper (syn. Polygonum hydropiper) by Loder atCSIRO, Australia in 1962. Polygodial is widely distributed, occurring in the roots, bark and leaves of several trees, in plants and...

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Radicinol

Radicinol is a mycotoxin isolated from Curvularia lunata (syn. Cochliobolus lunata) by researchers at Nagoya University, Japan in 1977. Subsequently, Radicinol has been found as a secondary metabolite in a diverse range of plant pathogenic fungi. ...

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