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Pitavastatin Calcium

Pitavastatin Calcium is the calcium salt of Pitavastatin, a compound that  inhibits cholesterol synthesis and displays cardioprotective properties. Pitavastatin may be usefully combined with zoledronic acid in cancer therapy. Mechanism of Action...

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Pluviatolide

Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin were reported as metabolites of the vine, Aristolochia...

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Podophyllotoxin

Podophyllotoxin, a natural, non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species, was first isolated in 1880. Serving as a model for antii-tumor properties, Podophyllotoxin has been used to inhibit the growth of various...

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Polygodial

Polygodial is a sesquiterpene dialdehyde first isolated from Persicaria hydropiper (syn. Polygonum hydropiper) by Loder atCSIRO, Australia in 1962. Polygodial is widely distributed, occurring in the roots, bark and leaves of several trees, in plants and...

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Polygodial Pyridazine

Polygodial Pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal,...

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Pretomanid

Pretomanid is a bicyclic nitroimidazole and small molecule pro-drug that is active against actively replicating and hypoxic non-replicating Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). It is activated by deazaflavin-dependent...

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Pyrantel (+)-tartrate salt

Pyrantel (+)-tartrate salt is an anthelmintic (anti-protozoal) that was first desribed in 1965 by Pfizer. It is effective against intestinal nematodes (roundworm, threadworm, and hookworm, nodular worm). The compound is soluble in DMSO. This product is...

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Pyripyropene A

Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at the Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol acyltransferase (ACAT) and the isozyme sterol...

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Quinine Hydrochloride

Quinine Hydrochloride is a naturally occurring chemical compound, an alkaloid, and potassium channel blocker. It is a stereoisomer of quinidine which contains an aromatic quinoline and a bicyclic quinuclidine.  It was first isolated from the bark of...

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Radicinol

Radicinol is a mycotoxin isolated from Curvularia lunata (syn. Cochliobolus lunata) by researchers at Nagoya University, Japan in 1977. Subsequently, Radicinol has been found as a secondary metabolite in a diverse range of plant pathogenic fungi. ...

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Remdesivir

Remdesivir is a broad-spectrum antiviral developed by Gilead Sciences. Remdesivir is a prodrug, and upon entry into cells, it is metabolized into the nuceotide triphosphate GS-441524. Remdesivir was investigated for activity for Ebola virus, but it was...

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Roccellic Acid

Roccellic Acid is a methyldodecylsuccinic acid isolated from Roccella spp. over 150 years ago, with the structure fullyelucidated by Akermark in 1962. Roccellic Acid is active against the oral bacteria, Streptococcus gordonii and Porphyromonas gingivalis...

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