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Polygodial

Polygodial is a sesquiterpene dialdehyde first isolated from Persicaria hydropiper (syn. Polygonum hydropiper) by Loder atCSIRO, Australia in 1962. Polygodial is widely distributed, occurring in the roots, bark and leaves of several trees, in plants and...

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Polygodial Pyridazine

Polygodial Pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal,...

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Pretomanid

Pretomanid is a bicyclic nitroimidazole and small molecule pro-drug that is active against actively replicating and hypoxic non-replicating Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). It is activated by deazaflavin-dependent...

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Pyrantel (+)-tartrate salt

Pyrantel (+)-tartrate salt is an anthelmintic (anti-protozoal) that was first desribed in 1965 by Pfizer. It is effective against intestinal nematodes (roundworm, threadworm, and hookworm, nodular worm). The compound is soluble in DMSO. This product is...

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Pyripyropene A

Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at the Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol acyltransferase (ACAT) and the isozyme sterol...

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Quinine HCl

Quinine Hydrochloride is a naturally occurring chemical compound, an alkaloid, and potassium channel blocker. It is a stereoisomer of quinidine which contains an aromatic quinoline and a bicyclic quinuclidine.  It was first isolated from the bark of...

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Radicinol

Radicinol is a mycotoxin isolated from Curvularia lunata (syn. Cochliobolus lunata) by researchers at Nagoya University, Japan in 1977. Subsequently, Radicinol has been found as a secondary metabolite in a diverse range of plant pathogenic fungi. ...

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Roccellic Acid

Roccellic Acid is a methyldodecylsuccinic acid isolated from Roccella spp. over 150 years ago, with the structure fullyelucidated by Akermark in 1962. Roccellic Acid is active against the oral bacteria, Streptococcus gordonii and Porphyromonas gingivalis...

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Salazinic Acid

Salazinic Acid is a depsidone lichen metabolite first reported over a 100 years ago and widely distributed across many lichen genera. Salazinic Acid is moderately active against Gram-positive bacteria and some Gram-negative bacteria (P. aeruginosa and S...

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Sartorypyrone B

Sartorypyrone B is a pentacyclic meroterpenoid metabolite isolated from Aspergillus (syn. Neosartorya) species. Whilesartorypyrone B possesses no antibiotic activity against S. aureus, P. aeruginosa. B. subtilis and E. coli, it is nonethelessscapable of...

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Seselin

Seselin is a pyranocoumarin isolated from the fruits of Seseli indicum by Spath and colleagues in 1939. Seselin wassubsequently isolated from a number of fruits of diverse species, most notably star anise. More recently, Seselin has beenisolated...

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Sparsomycin

Sparsomycin is a nucleotide analogue produced by Streptomyces sparsogenes isolated by researchers at Upjohn (now Pfizer) in 1962. Sparsomycin binds to the 50S ribosomal subunit and inhibits protein synthesis via peptidyl transferase inhibition. ...

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