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Monomethylsulochrin

Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits VEGF leading to inhibition of capillary-like tube...

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Manumycin A

Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has...

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Norstictic Acid

Norstictic acid was first reported in 1934 as a metabolite produced by the lichen, Lobaria pulmonaria, along with two relatedcompounds. Norstictic acid has antioxidant, antimicrobial and antitumor activities. Norstictic acid treatment...

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Novobiocic Acid

Novobiocic Acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic Acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic Acid exhibits little antibacterial...

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Oxozeaenol, (5E)-7-

(5E)-7-Oxozeaenol ("iso-LL Z1640-2") is a resorcylic acid lactone belonging to the Zearalenone class, recognised as a minor metabolite of the fungus, Drechslera portulacae. (5E)-7-Oxozeaenol was rediscovered as a major analog of a resorcylic acid lactone...

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Pluviatolide

Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin were reported as metabolites of the vine, Aristolochia...

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Polygodial

Polygodial is a sesquiterpene dialdehyde first isolated from Persicaria hydropiper (syn. Polygonum hydropiper) by Loder atCSIRO, Australia in 1962. Polygodial is widely distributed, occurring in the roots, bark and leaves of several trees, in plants and...

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Polygodial Pyridazine

Polygodial Pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal,...

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Penicinoline

Penicinoline is an unusual quinolinone alkaloid isolated from a mangrove endophytic Penicillium species by researchers at the Key Laboratory of Marine Drugs in collaboration with Syngenta and first reported in 2010. Penicinoline posseses broadspectrum...

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Pyrantel (+)-tartrate salt

Pyrantel (+)-tartrate salt is an anthelmintic (anti-protozoal) that was first desribed in 1965 by Pfizer. It is effective against intestinal nematodes (roundworm, threadworm, and hookworm, nodular worm). The compound is soluble in DMSO. This product is...

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Oritavancin

Oritavancin is a semi-synthetic glycopeptide antibiotic that is an analog of vancomycin. It has bactericidal activity against Gram-positive bacteria. Mechanism of Action Like other glycopeptides and lipoglycopeptides, Oritavancin inhibits...

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Pyripyropene A

Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at the Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol acyltransferase (ACAT) and the isozyme sterol...

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