Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Acadesine was originally identified as a metabolite of Bacillus species and was shown to accumulate in the culture medium of E. coli under sulphonamide stasis. Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine. Ithas...
17-Dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG, alvespimycin) is a semi-synthetic derivative of the benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus in which the methoxy group attached to...
Sulfasalazine is a synthetic salicylic acid derivative and sulfonamide which can act as an antirhematic and gastrointestinal agent. It is formulated as a prodrug, and is metabolized into active metabolites sulfapyridine and mesalazine (5-aminosalicylic...
Baloxavir Marboxil is a synthetic antiviral compound. It has activity against viruses causing influenza A and influenza B. It originated by Shionogi (Japan). It is a small molecule inhibitor of cap-dependent endonuclease found in of influenza A and B...
Sulfachloropyridazine Sodium is the sodium salt of Sulfachloropyridazine, a sulfonamide antibiotic. It has been used to treat the bacteria causing urinary tract infections and is commonly used in aquaculture and animal husbandry. Sulfachloropyridazine...
Pretomanid is a bicyclic nitroimidazole and small molecule pro-drug that is active against actively replicating and hypoxic non-replicating Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). It is activated by deazaflavin-dependent...
Podophyllotoxin, a natural, non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species, was first isolated in 1880. Serving as a model for antii-tumor properties, Podophyllotoxin has been used to inhibit the growth of various...
4-Epitetracycline ammonium salt, EvoPure® is a highly purified version of 4-Epitetracycline, an epimer of Tetracycline. Tetracycline is a broad-spectrum antibacterial and selection agent. We also offer:4-Epitetracycline Hydrochloride, EvoPure®...
Banksialactone A is the simplest and major analogue of a family of isochromanones isolated from an Australian fungus,Aspergillus banksianus, by researchers at Macquarie University, Australia and Microbial Screening Technologies in 2018. While...
Butyrolactone II is one of a family of four butyrolactones isolated from the fungus, Aspergillus terreus, by Yamamoto andcollaborators at Kanazawa University, Japan in 1983. Butyrolactone II inhibits soybean lipoxygenase (LOX) and α-glucosidase...
Dihydroeuphol is a tetracyclic triterpene isolated from members of the genus Euphorbia. There are no published reports of the biological activity of dihydroeuphol, however its analogue, euphol, has cytotoxic, antinociceptive and antioxidant activity. ...
Tosufloxacin Tosylate is a fluoroquinolone antibacterial agent. It is a small organic compound and racemate, comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate. It can act as a mimetic of the neural glycan LewisX (LeX), thus it can...
