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IT-143B is a rare, higher homolog of the piericidin class isolated from a Streptomyces sp. by Taiho Pharmaceuticals incollaboration with Chinese researchers in 1996. IT-143B is active against the fungus, Aspergillus fumigatus, and the Gram-positive...
Limonin is a highly oxygenated terpenoid which forms the core structure of the citrus limonoid metabolites found mostly in the seeds, fruits and peel tissues of citrus. Limonin was first isolated over 175 years ago. In Australia, Limonin was isolated...
Lupeol is a pentacyclic lupane triterpene produced by various fruits, vegetables and other plants, first isolated in 1898 and published in 1907. Lupeol is reported to have very diverse biological effects, including anti-inflammatory, anti-diabetic,...
Norstictic acid was first reported in 1934 as a metabolite produced by the lichen, Lobaria pulmonaria, along with two relatedcompounds. Norstictic acid has antioxidant, antimicrobial and antitumor activities. Norstictic acid treatment...
(5E)-7-Oxozeaenol ("iso-LL Z1640-2") is a resorcylic acid lactone belonging to the Zearalenone class, recognised as a minor metabolite of the fungus, Drechslera portulacae. (5E)-7-Oxozeaenol was rediscovered as a major analog of a resorcylic acid lactone...
Polygodial Pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal,...
Penicinoline is an unusual quinolinone alkaloid isolated from a mangrove endophytic Penicillium species by researchers at the Key Laboratory of Marine Drugs in collaboration with Syngenta and first reported in 2010. Penicinoline posseses broadspectrum...
Radicinol is a mycotoxin isolated from Curvularia lunata (syn. Cochliobolus lunata) by researchers at Nagoya University, Japan in 1977. Subsequently, Radicinol has been found as a secondary metabolite in a diverse range of plant pathogenic fungi. ...
Roccellic Acid is a secondary metabolite and methyldodecylsuccinic acid isolated from lichen Roccella spp. over 150 years ago, with the structure fully elucidated by Akermark in 1962. Roccellic Acid is active against the oral bacteria, Streptococcus...
Tropodithietic Acid is a potent antibiotic isolated from a Roseobacter strain by Brinkhoff and colleagues at the University of Gottingen, Germany in 2004. Tropodithietic Acid is a strong inhibitor of marine bacteria, promoter of algal health and a potent...
Methotrexate Sodium is a selective agent for dihydrofolate reductase (DHFR)- transfected cells and a nucleic acid synthesis inhibitor in protein expression systems. It is commonly used as an ancillary material in upstream biomanufacturing applications...
Phloroglucinol (syn: 1,3,5-trihydroxybenzene) is an organic biochemical. It is the core structure of a large family of substituted phenolics with broad, albeit weak, biological activity. Phloroglucinol is a useful metabolite for HPLC/DAD and bioassay...
