Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Himgaline is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia native to northern Australia, and reported in 1967 by Ritchie and co-workers,...
Himbosine is apiperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia species native to Australia and South East Asia, and reported in 1967 by Taylor...
Multiflorenol is a triterpenoid found in the geranium family and other flowering plants, first isolated and the structure elucidated by Khastgir and Sengupta in 1961. Multiflorenol was subsequently...
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid derived from members of the Crotolaria species, longknown to cause poisoining among livestock. Monocrotaline causes pulmonary artery...
Methylspinazarin is a rare naphthoquinone pigment produced by a strain of Streptomyces filipinensis, isolated by Nagatsu and colleagues at Ochanomizu University, Japan in 1973. Methylspinazarin...
Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits...
Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin...
Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at the Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol...
Phenylpyropene A is a meroterpenoid isolated from Penicillium griseofulvum by researchers at the Korean Research Institute of Bioscience and Biotechnology in 2002. Phenylpyropene A inhibits...
Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide...
Territrem B is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem B is a potent insecticide...
Terrelulamide A is a rare lumazine pseudo-tripeptide metabolite isolated from a marine strain of Aspergillus terreus byresearchers at Seoul National University, Korea reported in 2015. Terrelulamide...
