Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Himgaline is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia native to northern Australia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. There are no specific...
Himbosine is apiperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia species native to Australia and South East Asia, and reported in 1967 by Taylor and co-workers, University of Sydney, Australia. The...
Multiflorenol is a triterpenoid found in the geranium family and other flowering plants, first isolated and the structure elucidated by Khastgir and Sengupta in 1961. Multiflorenol was subsequently isolated by Ritchie and Taylor from the Australian...
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid derived from members of the Crotolaria species, longknown to cause poisoining among livestock. Monocrotaline causes pulmonary artery hypertension, right ventricularhypertrophy, and...
Methylspinazarin is a rare naphthoquinone pigment produced by a strain of Streptomyces filipinensis, isolated by Nagatsu and colleagues at Ochanomizu University, Japan in 1973. Methylspinazarin inhibits catechol-O-methyl transferase (COMT) and exhibits a...
Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits VEGF leading to inhibition of capillary-like tube...
Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin were reported as metabolites of the vine, Aristolochia...
Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at the Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol acyltransferase (ACAT) and the isozyme sterol...
Phenylpyropene A is a meroterpenoid isolated from Penicillium griseofulvum by researchers at the Korean Research Institute of Bioscience and Biotechnology in 2002. Phenylpyropene A inhibits conversion of cholesterol to cholesteryl esters via inhibition...
Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of...
Territrem B is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem B is a potent insecticide acting via irreversible inhibition of...
Terrelulamide A is a rare lumazine pseudo-tripeptide metabolite isolated from a marine strain of Aspergillus terreus byresearchers at Seoul National University, Korea reported in 2015. Terrelulamide A is reported as having metabolic effects and improves...