Bioactive small molecules are organic compounds that have a low molecular weight (900 daltons). Most pharmaceutical drugs are small molecules. Larger structures such as nucleic acids, proteins, and many polysaccharides are not small molecules.
Emestrin is a macrocyclic mycotoxin first isolated from Emericella striata by researchers at Hoshi Unveristy, Japan in 1985. Emestrin posseses a unique epidithiodioxopiperazine ring as part of a larger heterologous macrocycle. Emestrin inhibits...
Himbacine is a piperidine alkaloid with a tricyclic lactone scaffold isolated from Galbulimima sp. (Himantandra sp.) by Ritchie and Taylor, University of Sydney, Australia in 1956. Himbacine is a potent M2 muscarinic receptor antagonist with selectivity...
Himbadine is a piperidine alkaloid with a polycyclic scaffold first isolated from Galbulimima sp. a magnolia species native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. The...
Himandridine is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimia sp., a magnolia native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia...
Himgaline is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia native to northern Australia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. There are no specific...
Himbosine is apiperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimima sp., a magnolia species native to Australia and South East Asia, and reported in 1967 by Taylor and co-workers, University of Sydney, Australia. The...
Multiflorenol is a triterpenoid found in the geranium family and other flowering plants, first isolated and the structure elucidated by Khastgir and Sengupta in 1961. Multiflorenol was subsequently isolated by Ritchie and Taylor from the Australian...
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid derived from members of the Crotolaria species, longknown to cause poisoining among livestock. Monocrotaline causes pulmonary artery hypertension, right ventricularhypertrophy, and...
Methylspinazarin is a rare naphthoquinone pigment produced by a strain of Streptomyces filipinensis, isolated by Nagatsu and colleagues at Ochanomizu University, Japan in 1973. Methylspinazarin inhibits catechol-O-methyl transferase (COMT) and exhibits a...
Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits VEGF leading to inhibition of capillary-like tube...
Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin were reported as metabolites of the vine, Aristolochia...
Pyripyropene A is a meroterpenoid isolated from Aspergillus fumigatus and published in 1993 by Omura and co-workers at the Kitasato Institute, Japan. Pyripyropene A has potent acyl-CoA:cholesterol acyltransferase (ACAT) and the isozyme sterol...
